Gene
fgg
- ID
- ZDB-GENE-040426-1998
- Name
- fibrinogen gamma chain
- Symbol
- fgg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in blood plasma; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; and multiple myeloma. Orthologous to human FGG (fibrinogen gamma chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56023 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgg | (2) | |
| CRISPR2-fgg | (2) | |
| CRISPR3-fgg | (2) | |
| MO1-fgg | N/A | Vo et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital afibrinogenemia | Alliance | Afibrinogenemia, congenital | 202400 |
| congenital afibrinogenemia | Alliance | Hypofibrinogenemia, congenital | 202400 |
| Dysfibrinogenemia, congenital | 616004 | ||
| Hypodysfibrinogenemia | 616004 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Domain | IPR012290 | Fibrinogen, alpha/beta/gamma chain, coiled coil domain |
| Family | IPR037579 | Fibrinogen/angiopoietin-like |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, coiled coil domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen/angiopoietin-like | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVG7 | InterPro | 431 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fgg:EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30K22 | ZFIN Curated Data | |
| Encodes | EST | fb60h05 | ||
| Encodes | EST | fb62e01 | ||
| Encodes | cDNA | MGC:56023 | ||
| Encodes | cDNA | MGC:174840 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192894 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213054 (1) | 1600 nt | ||
| Genomic | GenBank:AL935184 (1) | 255909 nt | ||
| Polypeptide | UniProtKB:Q7ZVG7 (1) | 431 aa |
- Zhang, H., Sun, C., Xia, Q., Li, P., Liu, K., Zhang, Y. (2024) Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Marine drugs. 22(10):
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Charlie-Silva, I., Feitosa, N.M., Pontes, L.G., Fernandes, B.H., Nóbrega, R.H., Gomes, J.M.M., Prata, M.N.L., Ferraris, F.K., Melo, D.C., Conde, G., Rodrigues, L.F., Aracati, M.F., Corrêa-Junior, J.D., Manrique, W.G., Superio, J., Garcez, A.S., Conceição, K., Yoshimura, T.M., Núñez, S.C., Eto, S.F., Fernandes, D.C., Freitas, A.Z., Ribeiro, M.S., Nedoluzhko, A., Lopes-Ferreira, M., Borra, R.C., Barcellos, L.J.G., Perez, A.C., Malafaia, G., Cunha, T.M., Belo, M.A.A., Galindo-Villegas, J. (2022) Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts. Frontiers in immunology. 13:1019201
- Zhang, Y., Ma, C., He, L., Liao, L., Guo, C., Wang, C., Gong, L., Zhou, H., Fu, K., Peng, C., Li, Y. (2022) Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. Oxidative medicine and cellular longevity. 2022:2232365
- Liao, L., Zhou, M., Wang, J., Xue, X., Deng, Y., Zhao, X., Peng, C., Li, Y. (2021) Identification of the Antithrombotic Mechanism of Leonurine in Adrenalin Hydrochloride-Induced Thrombosis in Zebrafish via Regulating Oxidative Stress and Coagulation Cascade. Frontiers in pharmacology. 12:742954
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Sheng, J., Meng, Q., Yang, Z., Guan, J., Zhao, Y., Zhang, J., Wang, Y., Zhao, L., Wang, Y. (2020) Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade. Phytomedicine : international journal of phytotherapy and phytopharmacology. 76:153263
- Vilar, R., Lukowski, S.W., Garieri, M., Di Sanza, C., Neerman-Arbez, M., Fish, R.J. (2020) Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis. Thrombosis and haemostasis. 121(4):433-448
- Yin, S.J., Luo, Y.Q., Zhao, C.P., Chen, H., Zhong, Z.F., Wang, S., Wang, Y.T., Yang, F.Q. (2020) Antithrombotic effect and action mechanism of Salvia miltiorrhiza and Panax notoginseng herbal pair on the zebrafish. Chinese Medicine. 15:35
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
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