Gene
fgg
- ID
- ZDB-GENE-040426-1998
- Name
- fibrinogen gamma chain
- Symbol
- fgg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in blood plasma; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; and multiple myeloma. Orthologous to human FGG (fibrinogen gamma chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56023 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital afibrinogenemia | Alliance | Afibrinogenemia, congenital | 202400 |
| congenital afibrinogenemia | Alliance | Hypofibrinogenemia, congenital | 202400 |
| Dysfibrinogenemia, congenital | 616004 | ||
| Hypodysfibrinogenemia | 616004 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Domain | IPR012290 | Fibrinogen, alpha/beta/gamma chain, coiled coil domain |
| Family | IPR037579 | Fibrinogen/angiopoietin-like |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, coiled coil domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen/angiopoietin-like | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVG7 | InterPro | 431 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available