Gene

fgg

ID

ZDB-GENE-040426-1998

Name

fibrinogen gamma chain

Symbol

fgg Nomenclature History

Previous Names

fb60h05 (1)
fb62e01 (1)
wu:fb60h05 (1)
wu:fb62e01 (1)
zgc:56023 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have signaling receptor binding activity. Involved in blood coagulation, fibrin clot formation. Predicted to localize to fibrinogen complex. Human ortholog(s) of this gene implicated in congenital afibrinogenemia and multiple myeloma. Is expressed in liver and yolk syncytial layer. Orthologous to human FGG (fibrinogen gamma chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56023 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgg Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital afibrinogenemia	Alliance	Afibrinogenemia, congenital	202400
congenital afibrinogenemia	Alliance	Hypofibrinogenemia, congenital	202400
		Dysfibrinogenemia, congenital	616004
		Hypodysfibrinogenemia	616004

Associated With fgg Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal

Domain Details Per Protein

Protein	Length	Fibrinogen, alpha/beta/gamma chain, coiled coil domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Fibrinogen, conserved site	Fibrinogen-like, C-terminal
UniProtKB:Q7ZVG7 InterPro	431

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fgg-201 (1) Ensembl	Ensembl	1,627 nt	Select Tool
mRNA	fgg-204 (1) Ensembl	Ensembl	1,575 nt	Select Tool ZFIN BLAST
ncRNA	fgg-002 (1) Ensembl	Ensembl	812 nt	Select Tool
ncRNA	fgg-003 (1) Ensembl	Ensembl	532 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fgg	polyclonal	fgg		Rabbit	WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations