Gene
dctn2
- ID
- ZDB-GENE-040426-1279
- Name
- dynactin 2 (p50)
- Symbol
- dctn2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including P granule organization; neurogenesis; and photoreceptor cell maintenance. Predicted to be located in vesicle. Predicted to be part of dynactin complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human DCTN2 (dynactin subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63867 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 9 figures from Jing et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dctn2 | N/A | Jing et al., 2009 |
| MO2-dctn2 | N/A | Jing et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR028133 | Dynamitin |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dynamitin |
|---|---|---|---|
| UniProtKB:Q7T3H1 | InterPro | 405 | |
| UniProtKB:A0A8M2BDJ6 | InterPro | 403 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(UAS:dctn2-2A-EGFP-CAAX) |
| 1 | Mathewson et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-125M22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63867 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201166 (1) | 2013 nt | ||
| Genomic | GenBank:BX950854 (1) | 171896 nt | ||
| Polypeptide | UniProtKB:Q7T3H1 (1) | 405 aa |
- Bercier, V., Hubbard, J.M., Fidelin, K., Duroure, K., Auer, T.O., Revenu, C., Wyart, C., Del Bene, F. (2019) Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Molecular neurodegeneration. 14:27
- Mathewson, A.W., Berman, D., Moens, C.B. (2019) Microtubules are required for the maintenance of planar cell polarity in monociliated floorplate cells. Developmental Biology. 452(1):21-33
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jing, X., and Malicki, J. (2009) Zebrafish ale oko, an essential determinant of sensory neuron survival and the polarity of retinal radial glia, encodes the p50 subunit of dynactin. Development (Cambridge, England). 136(17):2955-2964
- Strasser, M.J., Mackenzie, N.C., Dumstrei, K., Nakkrasae, L.I., Stebler, J., and Raz, E. (2008) Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development. BMC Developmental Biology. 8:58
- Tsujikawa, M., Omori, Y., Biyanwila, J., and Malicki, J. (2007) Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 104(37):14819-14824
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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