Gene
cflara
- ID
- ZDB-GENE-030826-3
- Name
- CASP8 and FADD-like apoptosis regulator a
- Symbol
- cflara Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sakamaki et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2599 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11641 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27804 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa27805 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41869 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Caspase-like domain superfamily | Death effector domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, p20 domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P2J9 | InterPro | 461 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cflara-201
(1)
|
Ensembl | 2,273 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cflar | monoclonal | Rabbit |
|
Cell Signaling Technology, Inc.
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31D5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-245J21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136515 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001313772 (1) | 2273 nt | ||
| Genomic | GenBank:BX323548 (1) | 222367 nt | ||
| Polypeptide | UniProtKB:A0A8M1P2J9 (1) | 461 aa |
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Méjécase, C., Nair, N., Sarkar, H., Soro-Barrio, P., Toms, M., Halliday, S., Linkens, K., Jaroszynska, N., Maurer, C., Owen, N., Moosajee, M. (2024) Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish. Antioxidants (Basel, Switzerland). 13(12):
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952
- Zhou, Z.J., Sun, L. (2016) Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Frontiers in cellular and infection microbiology. 6:76
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Essers, P.B., Klasson, T.D., Pereboom, T.C., Mans, D.A., Nicastro, M., Boldt, K., Giles, R.H., and MacInnes, A.W. (2015) The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Oncogene. 146(3):789-800.e8
- Sakamaki, K., Iwabe, N., Iwata, H., Imai, K., Takagi, C., Chiba, K., Shukunami, C., Tomii, K., Ueno, N. (2015) Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Biochemistry and biophysics reports. 3:175-189
- Zhang, D., Golubkov, V.S., Han, W., Correa, R.G., Zhou, Y., Lee, S., Strongin, A.Y., Dong, P.D. (2014) Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival. Developmental Biology. 395(1):96-110
- Xu, L., Yin, W., Xia, J., Peng, M., Li, S., Lin, S., Pei, A., and Shum, X. (2012) An anti-apoptotic role of SNX7 is required for liver development in zebrafish. Hepatology (Baltimore, Md.). 55(6):1985-1993
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