Gene

atp6v1b2

ID
ZDB-GENE-030711-4
Name
ATPase H+ transporting V1 subunit B2
Symbol
atp6v1b2 Nomenclature History
Previous Names
  • atp6v1bb
  • vatB2 (1)
  • fj51e01
  • wu:fj51e01 (1)
  • zgc:109771
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have ATP binding activity. Predicted to be involved in ATP metabolic process and proton transmembrane transport. Predicted to localize to proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy. Orthologous to human ATP6V1B2 (ATPase H+ transporting V1 subunit B2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Zhao et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp6v1b2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant congenital deafness with onychodystrophy Alliance Deafness, congenital, with onychodystrophy, autosomal dominant 124480
Zimmermann-Laband syndrome 2 616455
Associated With atp6v1b2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Domain IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Domain IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Family IPR005723 ATPase, V1 complex, subunit B
Family IPR022879 V-type ATP synthase regulatory subunit B/beta
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length ATPase, alpha/beta subunit, nucleotide-binding domain, active site ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain ATPase, V1 complex, subunit B P-loop containing nucleoside triphosphate hydrolase V-type ATP synthase regulatory subunit B/beta
UniProtKB:Q568W2 196
UniProtKB:F6P5H1 197
UniProtKB:A4FUM8 509
UniProtKB:Q8QHA6 509
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-atp6v1b2 Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations