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ZIRC
ZFIN ID: ZDB-GENE-030619-14
Gene Name: polo-like kinase 4 (Drosophila)
Gene Symbol: plk4    Nomenclature History

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Previous Names: stk18 (1), wu:fi33g07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in centriole assembly; cilium assembly; and developmental growth. Predicted to localize to several cellular components, including the deuterosome; microtubule organizing center; and nucleolus. Used to study ciliopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Is expressed in brain; eye; nervous system; and pronephros. Orthologous to human PLK4 (polo like kinase 4).
Genome Resources: Alliance (1),  Gene:368390 (1),  Ensembl(GRCz11):ENSDARG00000004576 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-plk4 N/A 1
MO2-plk4 N/A 1
MO3-plk4 N/A 1
DISEASE ASSOCIATED WITH plk4 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
microcephaly and chorioretinopathy 2 Alliance Microcephaly and chorioretinopathy, autosomal recessive, 2 616171
DISEASE ASSOCIATED WITH plk4 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
ciliopathy AB/TU + MO2-plk4 + MO3-plk4 standard conditions Martin et al., 2014
GENE ONTOLOGY
Ontology GO Term
Biological Process centriole assembly (more)
Cellular Component centriole (more)
Molecular Function protein serine/threonine kinase activity (more)
GO Terms (all 24)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA plk4-201 (1)    Ensembl 3297
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM plk4 No data available
MARKER RELATIONSHIPS
plk4 Contained in: [BAC] DKEY-21A6 (1) (order this)
plk4 Encodes: [EST] fi33g07
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001118892 (1) 3299 bp
Genomic GenBank:CR405694 (1) 207188 bp Blast at MegaBLAST
Polypeptide UniProtKB:F1RB74 (1) 941 aa
Sequence Clusters UniGene:80660 (1)
Sequence Information (all 15)
ORTHOLOGY for plk4 ( Chr: 17 )
CITATIONS (25)