Gene
celsr1a
- ID
- ZDB-GENE-030616-78
- Name
- cadherin EGF LAG seven-pass G-type receptor 1a
- Symbol
- celsr1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; neural tube development; and stem cell population maintenance. Predicted to be located in plasma membrane. Is expressed in several structures, including axis; germ ring; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015399Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024549Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mh36 | unknown | Unknown | Unknown | ENU | |
| mh104 | unknown | Unknown | Unknown | CRISPR | |
| mh202Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa6951 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7553 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa18077 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26315 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26316 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-celsr1a | Li et al., 2020 | |
| CRISPR2-celsr1a | Li et al., 2020 | |
| MO1-celsr1a | N/A | (3) |
| MO2-celsr1a | N/A | Formstone et al., 2005 |
| MO3-celsr1a | N/A | Formstone et al., 2005 |
| MO4-celsr1a | N/A | (2) |
| MO5-celsr1a | N/A | (2) |
| MO6-celsr1a | N/A | Qiao et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 9 | 619319 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | GAIN domain, N-terminal | GAIN domain superfamily | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Laminin G domain | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B933 | InterPro | 3031 | |||||||||||||||
| UniProtKB:F1R9W4 | InterPro | 3044 | |||||||||||||||
| UniProtKB:A0A8M3ARK0 | InterPro | 3045 | |||||||||||||||
| UniProtKB:A0A8M3ARU0 | InterPro | 3018 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
celsr1a-201
(1)
|
Ensembl | 11,760 nt | ||
| mRNA |
celsr1a-202
(1)
|
Ensembl | 9,089 nt | ||
| mRNA |
celsr1a-203
(1)
|
Ensembl | 11,679 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-263O4 | ZFIN Curated Data | |
| Contained in | BAC | RP71-6L08 | ZFIN Curated Data | |
| Contained in | BAC | RP71-22E02 | ZFIN Curated Data | |
| Encodes | EST | eu873 | Thisse et al., 2005 | |
| Encodes | EST | eu886 | Thisse et al., 2005 | |
| Encodes | EST | fb15b11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005168547 (1) | 10327 nt | ||
| Genomic | GenBank:AL645790 (2) | 165257 nt | ||
| Polypeptide | UniProtKB:A0A8M3ARK0 (1) | 3045 aa |
- Wang, H., Zaiser, F., Eckert, P., Ruf, J., Kayser, N., Veenstra, A.C., Müller, M., Haas, R., Walz, G., Yakulov, T.A. (2023) Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Biochemical and Biophysical Research Communications. 673:9159-15
- Joshi, B., Gaur, H., Hui, S.P., Patra, C. (2022) Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish. Developmental Neurobiology. 82(2):192-213
- Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
- Menon, T., Borbora, A.S., Kumar, R., Nair, S. (2020) Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Developmental Biology. 468(1-2):26-40
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Yakulov, T.A., Todkar, A.P., Slanchev, K., Wiegel, J., Bona, A., Groß, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T.B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., de Tullio, P., Jouret, F., Kramer-Zucker, A., Walz, G. (2018) CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nature communications. 9:3660
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Qiao, X., Liu, Y., Li, P., Chen, Z., Li, H., Yang, X., Finnell, R.H., Yang, Z., Zhang, T., Qiao, B., Zheng, Y., Wang, H. (2016) Genetic analysis of rare coding mutations in CELSR1-3 in Chinese Congenital Heart and Neural Tube Defects. Clinical science (London, England : 1979). 130(24):2329-2340
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Harty, B.L., Krishnan, A., Sanchez, N.E., Schiöth, H.B., Monk, K.R. (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 16:62
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