Gene
celsr1a
- ID
- ZDB-GENE-030616-78
- Name
- cadherin EGF LAG seven-pass G-type receptor 1a
- Symbol
- celsr1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; neural tube development; and stem cell population maintenance. Predicted to be located in plasma membrane. Is expressed in several structures, including axis; germ ring; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 9 | 619319 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR002049 | Laminin-type EGF domain |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Domain | IPR032471 | GAIN domain, N-terminal |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
| Homologous_superfamily | IPR046338 | GAIN domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | GAIN domain, N-terminal | GAIN domain superfamily | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Laminin G domain | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B933 | InterPro | 3031 | |||||||||||||||
| UniProtKB:F1R9W4 | InterPro | 3044 | |||||||||||||||
| UniProtKB:A0A8M3ARK0 | InterPro | 3045 | |||||||||||||||
| UniProtKB:A0A8M3ARU0 | InterPro | 3018 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
celsr1a-201
(1)
|
Ensembl | 11,760 nt | ||
| mRNA |
celsr1a-202
(1)
|
Ensembl | 9,089 nt | ||
| mRNA |
celsr1a-203
(1)
|
Ensembl | 11,679 nt |
Interactions and Pathways
No data available
Plasmids
No data available