ZFIN ID: ZDB-GENE-030411-5
Gene Name: keratin 8
Gene Symbol: krt8    Nomenclature History

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Previous Names: krt2-8 (1), cb186 (1), DreK8 (1), etID33550.23 (1), etID43142.23 (1), etID43142.8 (1), sb:cb186 (1), wu:fa20h05 (1), wu:fa95h10 (1), wu:fb96c06 (1), zf-K8 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to localize to cytoplasm. Is expressed in several structures, including EVL; cardiovascular system; integument; pectoral fin; and sensory system. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to several human genes including KRT8 (keratin 8).
Genome Resources: Alliance (1),  Gene:797433 (1),  Ensembl(GRCz11):ENSDARG00000058358 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1629 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31084 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37629 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43921 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-krt8 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH krt8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cirrhosis, cryptogenic 215600
    {Cirrhosis, noncryptogenic, susceptibility to} 215600
    DISEASE ASSOCIATED WITH krt8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasm (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA krt8-201 (1)    Ensembl 2214
    ncRNA krt8-002 (1)    Ensembl 784
    krt8-003 (1)    Ensembl 793
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM krt8
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-0.6opn1lw1-krt8:GFP) krt8opn1lw1 GFP Danio rerio 2 2
    Tg(-1.9mylpfa:fsta,krt8:EGFP) krt8mylpfa EGFPfsta Danio rerio 1 2
    Tg(krt8:LEXPR,LEXOP:EGFP) krt8 EGFP Danio rerio 1 2
    Tg(krt8:LEXPR,LEXOP:EGFP-kras_G12V) krt8 EGFPkras Danio rerio 1 2
    MARKER RELATIONSHIPS
    krt8 Contained in: [BAC] CH211-133J6 (1)
    krt8 Encodes: [EST] cb186 (2) (order this), fa20h05 (1), fa95h10 (1), fb96c06 (1)
    [cDNA] MGC:85764 (1), MGC:174782 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200080 (1) 2220 nt
    Genomic GenBank:CR450756 (1) 131145 nt
    Select Tool
    Polypeptide UniProtKB:A8WGN0 (1) 520 aa
    Sequence Information (all 30)
    ORTHOLOGY for krt8 ( Chr: 23 )
    CITATIONS (65)