Gene

mib1

ID

ZDB-GENE-030404-2

Name

MIB E3 ubiquitin protein ligase 1

Symbol

mib1 Nomenclature History

Previous Names

mib
cg5841 (1)
chunp6889
fe47f05
im:7148100 (1)
KIAA1323 (1)
mind bomb
white tail (3)
wit (3)
wu:fe47f05 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Enables identical protein binding activity. Contributes to ubiquitin-protein transferase activity. Acts upstream of or within several processes, including nervous system development; sensory system development; and tube morphogenesis. Located in endocytic vesicle and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in blood vessel; nervous system; neural tube; and pectoral fin. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148100 (1 image)
eu763 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 139 figures from 84 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mib1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Left ventricular noncompaction 7	615092

Associated With mib1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
epilepsy	mib1^{hi904Tg/hi904Tg}	standard conditions	Hortopan et al., 2010

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR010606	Mib-herc2
Domain	IPR040847	Mind bomb, SH3 repeat domain
Domain	IPR042056	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037252	Mib/herc2 domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type	Mib-herc2	Mib/herc2 domain superfamily	Mind bomb, SH3 repeat domain	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:H9GYU5 InterPro	1041
UniProtKB:A0A8M3AMW2 InterPro	1017
UniProtKB:Q804S5 InterPro	1030
UniProtKB:A0A8M3AVC7 InterPro	1006
UniProtKB:A0A8M3AMW8 InterPro	1006
UniProtKB:A0A8M3AYD8 InterPro	1030
UniProtKB:A0A8M3ANM1 InterPro	1040

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mib1-201 (1) Ensembl	Ensembl	4,673 nt	Select Tool ZFIN BLAST
mRNA	mib1-202 (1) Ensembl	Ensembl	3,227 nt	Select Tool ZFIN BLAST
mRNA	mib1-204 (1) Ensembl	Ensembl	3,293 nt	Select Tool ZFIN BLAST
mRNA	mib1-205 (1) Ensembl	Ensembl	698 nt	Select Tool ZFIN BLAST
mRNA	mib1-206 (1) Ensembl	Ensembl	712 nt	Select Tool ZFIN BLAST
ncRNA	mib1-005 (1) Ensembl	Ensembl	1,647 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations