Gene

mib1

ID
ZDB-GENE-030404-2
Name
MIB E3 ubiquitin protein ligase 1
Symbol
mib1 Nomenclature History
Previous Names
  • mib
  • cg5841 (1)
  • chunp6889
  • fe47f05
  • im:7148100 (1)
  • KIAA1323 (1)
  • mind bomb
  • white tail (3)
  • wit (3)
  • wu:fe47f05 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits identical protein binding activity and ubiquitin-protein transferase activity. Involved in several processes, including animal organ development; nervous system development; and tube morphogenesis. Localizes to endocytic vesicle; perinuclear region of cytoplasm; and protein-containing complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Is expressed in nervous system; neural tube; and pectoral fin. Orthologous to human MIB1 (mindbomb E3 ubiquitin protein ligase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
131 figures from 79 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mib1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Left ventricular noncompaction 7 615092
Associated With mib1 Via Experimental Models
Human Disease Fish Conditions Citations
epilepsy mib1hi904Tg/hi904Tg standard conditions Hortopan et al., 2010
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000433 Zinc finger, ZZ-type
Domain IPR001841 Zinc finger, RING-type
Domain IPR010606 Mib-herc2
Domain IPR040847 Mind bomb, SH3 repeat domain
Domain IPR042056 E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Homologous_superfamily IPR037252 Mib/herc2 domain superfamily
Homologous_superfamily IPR043145 Zinc finger, ZZ-type superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type Mib-herc2 Mib/herc2 domain superfamily Mind bomb, SH3 repeat domain Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, ZZ-type Zinc finger, ZZ-type superfamily
UniProtKB:A0A0R4IHW3 1038
UniProtKB:Q804S5 1030
UniProtKB:H9GYU5 1041
UniProtKB:A0A0R4IZE1 233
UniProtKB:B3DGQ0 1041
UniProtKB:A0A140LFN2 237
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations