ZFIN ID: ZDB-GENE-030404-2
Gene Name: mindbomb E3 ubiquitin protein ligase 1
Gene Symbol: mib1    Nomenclature History

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Previous Names: mib, cg5841 (1), chunp6889, fe47f05, im:7148100 (1), KIAA1323 (1), mind bomb, white tail (3), wit (3), wu:fe47f05 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits protein homodimerization activity and ubiquitin-protein transferase activity. Involved in several processes, including animal organ development; nervous system development; and tube morphogenesis. Localizes to the endocytic vesicle; perinuclear region of cytoplasm; and protein-containing complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Is expressed in nervous system; neural tube; and pectoral fin. Orthologous to human MIB1 (mindbomb E3 ubiquitin protein ligase 1).
Genome Resources: Alliance (1),  Gene:352910 (1),  Ensembl(GRCz11):ENSDARG00000102184 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 9 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148100]
  1 figure (1 image) from Thisse et al., 2005 [eu763]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi904Tg Transgenic Insertion Exon 4 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m132 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m178 Point Mutation Unknown Premature Stop ENU
    mib1_unspecified Unspecified Unknown Unknown
    nn2000 Point Mutation Unknown Premature Stop ENU
    nn2001 Insertion Unknown Unknown ENU
    sa31118 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44378 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ta52b Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tfi91 Point Mutation Unknown Premature Stop
    tfi101 Point Mutation Unknown Missense
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mib1
    1
    CRISPR2-mib1
    1
    CRISPR3-mib1
    1
    MO1-mib1 N/A 10
    MO2-mib1 N/A 1
    MO3-mib1 N/A 1
    MO4-mib1 N/A 2
    PHENOTYPE
    Data: 124 figures from 73 publications
    Observed in:
    DISEASE ASSOCIATED WITH mib1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Left ventricular noncompaction 7 615092
    DISEASE ASSOCIATED WITH mib1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    epilepsy mib1hi904Tg/hi904Tg standard conditions Hortopan et al., 2010
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein autoubiquitination (more)
    Cellular Component cytoplasm (more)
    Molecular Function ubiquitin-protein transferase activity (more)
    GO Terms (all 84)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000433 Zinc finger, ZZ-type
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR010606 Mib-herc2
    Domain IPR020683 Ankyrin repeat-containing domain
    Domain IPR040847 Mind bomb, SH3 repeat domain
    Domain IPR042056 E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type
    Family IPR017066 E3 ubiquitin-protein ligase BOI-like
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    Homologous_superfamily IPR037252 Mib/herc2 domain superfamily
    Repeat IPR002110 Ankyrin repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mib1-201 (1)    Ensembl 4673
    mib1-202 (1)    Ensembl 3227
    mib1-205 (1)    Ensembl 698
    mib1-206 (1)    Ensembl 712
    ncRNA mib1-005 (1)    Ensembl 1647
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mib1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(col2a1a:mib_M1013R) col2a1a mib1 Danio rerio 1 2
    Tg(hsp70l-mib1:EGFP) hsp70lmib1 EGFP Danio rerio 2 2
    MARKER RELATIONSHIPS
    mib1 Contained in: [BAC] DKEY-2P18 (1) (order this)
    [Fosmid] CH1073-221A23 (1)
    mib1 Encodes: [EST] eu763 (1), fe47f05, IMAGE:7148100 (1)
    [cDNA] MGC:193576 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173286 (1) 3293 nt
    Genomic GenBank:BX842700 (1) 198258 nt
    Select Tool
    Polypeptide UniProtKB:B3DGQ0 (1) 1041 aa
    Sequence Information (all 39)
    ORTHOLOGY for mib1 ( Chr: 2 )
    CITATIONS (257)