Gene

dio2

ID

ZDB-GENE-030327-4

Name

iodothyronine deiodinase 2

Symbol

dio2 Nomenclature History

Previous Names

D2 (1)
Deio2 (1)
cb684 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Exhibits thyroxine 5'-deiodinase activity. Involved in several processes, including chordate embryonic development; developmental pigmentation; and regulation of neural retina development. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in hypertension. Is expressed in several structures, including digestive system; eye; hypophysis; male organism; and thyroid follicle. Orthologous to human DIO2 (iodothyronine deiodinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 22 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73279 (1 image)
cb684 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 27 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dio2 Human Ortholog

No data available

Associated With dio2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
glucose metabolism disease	dio2^lv1/lv1 (AB)	standard conditions	Houbrechts et al., 2019
glucose metabolism disease	dio2^lv2/lv2 (AB)	standard conditions	Houbrechts et al., 2019
hypothyroidism	dio2^lv1/lv1 (AB)	standard conditions	Houbrechts et al., 2019
hypothyroidism	dio2^lv2/lv2 (AB)	standard conditions	Houbrechts et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008261	Iodothyronine deiodinase, active site
Family	IPR000643	Iodothyronine deiodinase
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily