Gene

hspb1

ID
ZDB-GENE-030326-4
Name
heat shock protein, alpha-crystallin-related, 1
Symbol
hspb1 Nomenclature History
Previous Names
  • hsp27 (1)
  • cb153 (1)
  • cb660 (1)
  • id:ibd2821
  • sb:cb660
  • zgc:103437
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Involved in regulation of myofibril size; response to arsenic-containing substance; and response to heat. Localizes to cytoplasm and nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
41 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hspb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease axonal type 2F Alliance Charcot-Marie-Tooth disease, axonal, type 2F 606595
distal hereditary motor neuropathy type 2B Alliance Neuronopathy, distal hereditary motor, type IIB 608634
Associated With hspb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002068 Alpha crystallin/Hsp20 domain
Domain IPR037876 Heat shock protein beta-1, ACD domain
Family IPR001436 Alpha crystallin/Small heat shock protein, animal type
Homologous_superfamily IPR008978 HSP20-like chaperone
Domain Details Per Protein
Protein Length Alpha crystallin/Hsp20 domain Alpha crystallin/Small heat shock protein, animal type Heat shock protein beta-1, ACD domain HSP20-like chaperone
UniProtKB:A4VAK4 199
UniProtKB:K7DYC3 66
UniProtKB:Q645R1 199
UniProtKB:Q5PR64 199
UniProtKB:Q5MCP0 199
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-hspb1 polyclonal
  • IHC
  • WB
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations