Gene
zic2b
- ID
- ZDB-GENE-030219-92
- Name
- zic family member 2 (odd-paired homolog, Drosophila) b
- Symbol
- zic2b Nomenclature History
- Previous Names
-
- zic2.2 (1)
- zic2l
- hm:zeh0655
- id:ibd5017
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including brain development; embryonic viscerocranium morphogenesis; and regulation of retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including germ ring; immature eye; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Teslaa et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| holoprosencephaly 5 | Alliance | Holoprosencephaly 5 | 609637 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GLI C2H2-type zinc-finger | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
|
UniProtKB:Q9DE40
|
427 |
Interactions and Pathways
No data available
Plasmids
No data available