Gene

impdh1b

ID
ZDB-GENE-030219-206
Name
IMP (inosine 5'-monophosphate) dehydrogenase 1b
Symbol
impdh1b Nomenclature History
Previous Names
  • id:ibd5035
  • si:dkey-31f5.7
  • wu:fa09h11
  • wu:fa99c03
  • zgc:113446
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have IMP dehydrogenase activity. Predicted to be involved in GTP biosynthetic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Is expressed in several structures, including digestive system; heart; nervous system; notochord; and pigment cell. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Li et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With impdh1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leber congenital amaurosis 11 613837
Retinitis pigmentosa 10 180105
Associated With impdh1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR015875 IMP dehydrogenase / GMP reductase, conserved site
Domain IPR000644 CBS domain
Domain IPR001093 IMP dehydrogenase/GMP reductase
Family IPR005990 Inosine-5'-monophosphate dehydrogenase
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel CBS domain IMP dehydrogenase/GMP reductase IMP dehydrogenase / GMP reductase, conserved site Inosine-5'-monophosphate dehydrogenase
UniProtKB:Q5RGV1 514
UniProtKB:A0A8M2BBW1 578
UniProtKB:A0A8M2BC24 603
UniProtKB:A0A8M6YZF2 317
UniProtKB:Q5RGV0 539
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-impdh2 polyclonal IgG Rabbit
  • IHC
Proteintech
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations