Gene
impdh2
- ID
- ZDB-GENE-030114-5
- Name
- IMP (inosine 5'-monophosphate) dehydrogenase 2
- Symbol
- impdh2 Nomenclature History
- Previous Names
-
- cb635 (1)
- wu:fb64g02
- wu:fc43f09
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable IMP dehydrogenase activity. Acts upstream of or within circadian rhythm. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; immature eye; mesoderm; muscle; and nervous system. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb635 (18 images)
- IMAGE:7166281 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Li et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [IMPDH2 enzyme activity, variation in] | 617995 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR015875 | IMP dehydrogenase / GMP reductase, conserved site |
| Domain | IPR000644 | CBS domain |
| Domain | IPR001093 | IMP dehydrogenase/GMP reductase |
| Family | IPR005990 | Inosine-5'-monophosphate dehydrogenase |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR046342 | CBS domain superfamily |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | CBS domain | CBS domain superfamily | IMP dehydrogenase/GMP reductase | IMP dehydrogenase / GMP reductase, conserved site | Inosine-5'-monophosphate dehydrogenase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B0UXP9
|
514 | ||||||
|
UniProtKB:Q7ZYW9
|
514 | ||||||
|
UniProtKB:A0A8M2BEA6
|
534 | ||||||
|
UniProtKB:A0A8M9Q3A2
|
558 | ||||||
|
UniProtKB:A0A8M9Q9I4
|
538 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
impdh2-201
(1)
|
Ensembl | 2,335 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-impdh2 | polyclonal | IgG | Rabbit |
|
Proteintech
|
1 |
Plasmids
No data available