Gene
lrrfip1a
- ID
- ZDB-GENE-030131-99
- Name
- leucine rich repeat (in FLII) interacting protein 1a
- Symbol
- lrrfip1a Nomenclature History
- Previous Names
-
- lrrfip1 (1)
- hm:zeh1367
- wu:fc06b04
- wu:fi15c07
- zeh1367
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Is expressed in adaxial cell; cardiovascular system; musculature system; retina; and somite. Orthologous to human LRRFIP1 (LRR binding FLII interacting protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150904 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14421 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lrrfip1a | Angueyra et al., 2023 | |
| CRISPR2-lrrfip1a | Angueyra et al., 2023 | |
| CRISPR3-lrrfip1a | Rodríguez-Ruiz et al., 2023 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019139 | Leucine-rich repeat flightless-interacting protein 1/2 |
Domain Details Per Protein
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lrrfip1a-202
(1)
|
Ensembl | 1,810 nt | ||
| mRNA |
lrrfip1a-203
(1)
|
Ensembl | 1,741 nt | ||
| mRNA |
lrrfip1a-204
(1)
|
Ensembl | 1,933 nt | ||
| mRNA |
lrrfip1a-205
(1)
|
Ensembl | 4,456 nt | ||
| mRNA |
lrrfip1a-206
(1)
|
Ensembl | 3,554 nt | ||
| mRNA |
lrrfip1a-207
(1)
|
Ensembl | 607 nt | ||
| mRNA |
lrrfip1a-208
(1)
|
Ensembl | 1,004 nt | ||
| mRNA |
lrrfip1a-209
(1)
|
Ensembl | 2,167 nt | ||
| mRNA |
lrrfip1a-211
(1)
|
Ensembl | 717 nt | ||
| mRNA |
lrrfip1a-212
(1)
|
Ensembl | 824 nt | ||
| ncRNA |
lrrfip1a-005
(1)
|
Ensembl | 882 nt | ||
| ncRNA |
lrrfip1a-008
(1)
|
Ensembl | 413 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-10D15 | ||
| Contained in | BAC | DKEY-191G15 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-74A11 | ZFIN Curated Data | |
| Encodes | EST | fc06b04 | ||
| Encodes | EST | fi15c07 | ||
| Encodes | EST | IMAGE:7150904 | Thisse et al., 2004 | |
| Encodes | EST | zeh1367 |
1 - 7 of 7
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021472174 (1) | 5165 nt | ||
| Genomic | GenBank:BX247888 (1) | 223425 nt | ||
| Polypeptide | UniProtKB:A0A8M9QBC1 (1) | 1420 aa |
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Rodríguez-Ruiz, L., Lozano-Gil, J.M., Naranjo-Sánchez, E., Martínez-Balsalobre, E., Martínez-López, A., Lachaud, C., Blanquer, M., Phung, T.K., García-Moreno, D., Cayuela, M.L., Tyrkalska, S.D., Pérez-Oliva, A.B., Mulero, V. (2023) ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome. EMBO Molecular Medicine. 15(10):e18142
- Tobia, C., Chiodelli, P., Barbieri, A., Buraschi, S., Ferrari, E., Mitola, S., Borsani, G., Guerra, J., Presta, M. (2019) Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. Frontiers in immunology. 10:1092
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Le, X., Pugach, E.K., Hettmer, S., Storer, N.Y., Liu, J., Wills, A.A., Dibiase, A., Chen, E.Y., Ignatius, M.S., Poss, K.D., Wagers, A.J., Langenau, D.M., and Zon, L.I. (2013) A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development (Cambridge, England). 140(11):2354-64
- Ton, C., Hwang, D.M., Dempsey, A.A., Tang, H.C., Yoon, J., Lim, M., Mably, J.D., Fishman, M.C., and Liew, C.C. (2000) Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Genome research. 10(12):1915-1927
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
1 - 10 of 10
Show