Gene
col14a1a
- ID
- ZDB-GENE-030131-9889
- Name
- collagen, type XIV, alpha 1a
- Symbol
- col14a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within basement membrane assembly and fin regeneration. Located in basement membrane. Is expressed in several structures, including integument; median fin fold; nervous system; pectoral fin bud; and pharyngeal arch. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human COL14A1 (collagen type XIV alpha 1 chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb382 (14 images)
- cb542 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bader et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010089Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la012845Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027681Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7420 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa10929 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11768 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11818 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12349 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12938 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22787 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-col14a1a | Nauroy et al., 2018 | |
| MO1-col14a1a | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002035 | von Willebrand factor, type A |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR048287 | Thrombospondin-like, N-terminal domain |
| Family | IPR050525 | Extracellular Matrix Assembly and Organization |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Collagen triple helix repeat | Concanavalin A-like lectin/glucanase domain superfamily | Extracellular Matrix Assembly and Organization | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Thrombospondin-like, N-terminal domain | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P888 | InterPro | 1840 | |||||||||
| UniProtKB:A0A8M9PDJ1 | InterPro | 1763 | |||||||||
| UniProtKB:F1R9Y1 | InterPro | 1864 | |||||||||
| UniProtKB:A0A8M3AHX6 | InterPro | 1794 | |||||||||
| UniProtKB:A0A8M3AQF5 | InterPro | 1796 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
col14a1a-201
(1)
|
Ensembl | 5,595 nt | ||
| mRNA |
col14a1a-202
(1)
|
Ensembl | 6,466 nt | ||
| mRNA |
col14a1a-203
(1)
|
Ensembl | 947 nt | ||
| mRNA |
col14a1a-204
(1)
|
Ensembl | 530 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-col14a1a | polyclonal | Rabbit |
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-274C22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-250B7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-45N10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-46J3 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-441J8 | ZFIN Curated Data | |
| Encodes | EST | cb382 | Thisse et al., 2001 | |
| Encodes | EST | cb542 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009292164 (1) | 11222 nt | ||
| Genomic | GenBank:CR848753 (2) | 174445 nt | ||
| Polypeptide | UniProtKB:A0A8M3AIZ5 (1) | 1879 aa |
- Daponte, V., Tonelli, F., Masiero, C., Syx, D., Exbrayat-Héritier, C., Biggiogera, M., Willaert, A., Rossi, A., Coucke, P.J., Ruggiero, F., Forlino, A. (2023) Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure. Matrix biology : journal of the International Society for Matrix Biology. 121:105-126
- Malbouyres, M., Guiraud, A., Lefrançois, C., Salamito, M., Nauroy, P., Bernard, L., Sohm, F., Allard, B., Ruggiero, F. (2022) Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 109:1-18
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F. (2018) FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE. Seminars in cell & developmental biology. 89:100-108
- Nauroy, P., Guiraud, A., Chlasta, J., Malbouyres, M., Gillet, B., Hughes, S., Lambert, E., Ruggiero, F. (2018) Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane. Matrix biology : journal of the International Society for Matrix Biology. 75-76:82-101
- Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L., Chávez, F.P. (2017) In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.. Frontiers in cellular and infection microbiology. 7:334
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645
- Bader, H.L., Lambert, E., Guiraud, A., Malbouyres, M., Driever, W., Koch, M., and Ruggiero, F.. (2013) Zebrafish collagen XIV is transiently expressed in epithelia and is required for proper function of certain basement membranes. The Journal of biological chemistry. 288(10):6777-6787
- Charvet, B., Guiraud, A., Malbouyres, M., Zwolanek, D., Guillon, E., Bretaud, S., Monnot, C., Schulze, J., Bader, H.L., Allard, B., Koch, M., and Ruggiero, F. (2013) Knockdown of col22a1 gene in zebrafish induces a muscular dystrophy by disruption of the myotendinous junction. Development (Cambridge, England). 140(22):4602-4613
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