Gene

chek2

ID
ZDB-GENE-030131-8942
Name
checkpoint kinase 2
Symbol
chek2 Nomenclature History
Previous Names
  • chk2 (1)
  • fa66f08
  • wu:fa66f08
  • zgc:55865
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in cellular response to DNA damage stimulus. Predicted to localize to cytoplasm and nucleus. Is expressed in eye; head; optic tectum; and proliferative region. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chek2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance {Breast cancer, susceptibility to} 114480
Li-Fraumeni syndrome 2 Alliance Li-Fraumeni syndrome 609265
osteosarcoma Alliance Osteosarcoma, somatic 259500
prostate cancer Alliance {Prostate cancer, familial, susceptibility to} 176807
{Breast and colorectal cancer, susceptibility to}
Associated With chek2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000253 Forkhead-associated (FHA) domain
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Forkhead-associated (FHA) domain Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site SMAD/FHA domain superfamily
UniProtKB:B0V1J5 503
UniProtKB:Q90ZY5 503
UniProtKB:Q803E2 503
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-chek2 polyclonal Rabbit
  • WB
Cell Signaling Technology, Inc.
2
Ab1-chek2 polyclonal Rabbit
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations