Gene

grna

ID
ZDB-GENE-030131-8434
Name
granulin a
Symbol
grna Nomenclature History
Previous Names
  • grn
  • pgrn-a (1)
  • progranulin (1)
  • sb:eu337
  • wu:fb11g12
  • wu:fj18f05
  • zfPGRN-A (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Acts upstream of or within several processes, including neuron differentiation; sensory system development; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be active in extracellular region. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
mde33Allele with one deletionExon 3Unknownzinc finger nuclease
mde54aAllele with one deletionExon 3Frameshift, Premature Stopzinc finger nuclease
mde54bAllele with one deletionExon 3Unknownzinc finger nuclease
mde54cAllele with one delinsExon 3Unknownzinc finger nuclease
sa6034Allele with one point mutationUnknownPremature StopENU
sa20026Allele with one point mutationUnknownPremature StopENU
sa33188Allele with one point mutationUnknownSplice SiteENU
sa38396Allele with one point mutationUnknownSplice SiteENU
zf3533Allele with one delinsUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With grna Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Alliance Aphasia, primary progressive 607485
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Alliance Frontotemporal dementia 2 607485
neuronal ceroid lipofuscinosis 11 Alliance Ceroid lipofuscinosis, neuronal, 11 614706
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Associated With grna Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000118 Granulin
Family IPR039036 Granulin family
Homologous_superfamily IPR037277 Granulin superfamily
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Domain Details Per Protein
Protein Additional Resources Length Granulin Granulin family Granulin superfamily
UniProtKB:A0A8M2BB97 InterPro 1138
UniProtKB:A0A8M9PEV4 InterPro 968
UniProtKB:A0A8M2BB61 InterPro 880
UniProtKB:A0A8M2BB98 InterPro 1053
UniProtKB:Q8QGN9 InterPro PDB 873
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA grna-201 (1) Ensembl 3,631 nt
mRNA grna-202 (1) Ensembl 4,160 nt
mRNA grna-203 (1) Ensembl 3,632 nt
mRNA grna-204 (1) Ensembl 567 nt
mRNA grna-205 (1) Ensembl 840 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-grna polyclonal Mouse
1
Ab1-grna polyclonal Rabbit
  • IHC
  • WB
1
Ab2-grna monoclonal IgG2b Rat
1
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(mylpfa:grna)
  • grna
  • Danio rerio
1 (2)
Tg(TETRE-CMV:HcRed,grna)
  • Danio rerio
1Chiang et al., 2021
Tg(ubb:grna-2A-mCherry)
  • Danio rerio
1Zhu et al., 2021
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-151M15ZFIN Curated Data
Contained inBACDKEY-197M10ZFIN Curated Data
EncodesESTeu337Thisse et al., 2005
EncodesESTfb11g12
EncodesESTfj18f05ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGRN17
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseGrn11
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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