Gene

grna

ID
ZDB-GENE-030131-8434
Name
granulin a
Symbol
grna Nomenclature History
Previous Names
  • grn
  • pgrn-a (1)
  • progranulin (1)
  • sb:eu337
  • wu:fb11g12
  • wu:fj18f05
  • zfPGRN-A (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Involved in axon extension; liver development; and skeletal muscle acetylcholine-gated channel clustering. Predicted to localize to extracellular region. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); and neuronal ceroid lipofuscinosis 11. Orthologous to human GRN (granulin precursor).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grna Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Alliance Aphasia, primary progressive 607485
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Alliance Frontotemporal lobar degeneration with ubiquitin-positive inclusions 607485
neuronal ceroid lipofuscinosis 11 Alliance Ceroid lipofuscinosis, neuronal, 11 614706
Associated With grna Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000118 Granulin
Family IPR039036 Granulin family
Homologous_superfamily IPR037277 Granulin superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-grna polyclonal Mouse
1
Ab1-grna polyclonal Rabbit
  • IHC
  • WB
1
Ab2-grna monoclonal IgG2b Rat
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations