Gene
grna
- ID
- ZDB-GENE-030131-8434
- Name
- granulin a
- Symbol
- grna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including neuron differentiation; sensory system development; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be active in extracellular region. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu337 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mde33 | Allele with one deletion | Exon 3 | Unknown | zinc finger nuclease | |
| mde54a | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | zinc finger nuclease | |
| mde54b | Allele with one deletion | Exon 3 | Unknown | zinc finger nuclease | |
| mde54c | Allele with one delins | Exon 3 | Unknown | zinc finger nuclease | |
| sa6034 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20026 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33188 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38396 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3533 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-grna | Zhu et al., 2021 | |
| MO1-grna | N/A | Laird et al., 2010 |
| MO2-grna | N/A | (2) |
| MO3-grna | N/A | Chitramuthu et al., 2010 |
| MO4-grna | N/A | (2) |
| MO5-grna | N/A | (4) |
| MO6-grna | N/A | (4) |
| MO7-grna | N/A | Walsh et al., 2017 |
| MO8-grna | N/A | Walsh et al., 2017 |
| MO9-grna | N/A | Chiang et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | Alliance | Aphasia, primary progressive | 607485 |
| Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | Alliance | Frontotemporal dementia 2 | 607485 |
| neuronal ceroid lipofuscinosis 11 | Alliance | Ceroid lipofuscinosis, neuronal, 11 | 614706 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Granulin | Granulin family | Granulin superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BB97 | InterPro | 1138 | |||
| UniProtKB:A0A8M9PEV4 | InterPro | 968 | |||
| UniProtKB:A0A8M2BB61 | InterPro | 880 | |||
| UniProtKB:A0A8M2BB98 | InterPro | 1053 | |||
| UniProtKB:Q8QGN9 | InterPro PDB | 873 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mylpfa:grna) |
|
| 1 | (2) | |
| Tg(TETRE-CMV:HcRed,grna) |
|
| 1 | Chiang et al., 2021 | |
| Tg(ubb:grna-2A-mCherry) |
| 1 | Zhu et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151M15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-197M10 | ZFIN Curated Data | |
| Encodes | EST | eu337 | Thisse et al., 2005 | |
| Encodes | EST | fb11g12 | ||
| Encodes | EST | fj18f05 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001361234 (1) | 4056 nt | ||
| Genomic | GenBank:BX901883 (2) | 241961 nt | ||
| Polypeptide | UniProtKB:A0A8M3B8B0 (1) | 1141 aa |
- Thomasen, P.B., Salasova, A., Kjaer-Sorensen, K., Woloszczuková, L., Lavický, J., Login, H., Tranberg-Jensen, J., Almeida, S., Beel, S., Kavková, M., Qvist, P., Kjolby, M., Ovesen, P.L., Nolte, S., Vestergaard, B., Udrea, A.C., Nejsum, L.N., Chao, M.V., Van Damme, P., Krivanek, J., Dasen, J., Oxvig, C., Nykjaer, A. (2023) SorCS2 binds progranulin to regulate motor neuron development. Cell Reports. 42:113333113333
- Zambusi, A., Novoselc, K.T., Hutten, S., Kalpazidou, S., Koupourtidou, C., Schieweck, R., Aschenbroich, S., Silva, L., Yazgili, A.S., van Bebber, F., Schmid, B., Möller, G., Tritscher, C., Stigloher, C., Delbridge, C., Sirko, S., Günes, Z.I., Liebscher, S., Schlegel, J., Aliee, H., Theis, F., Meiners, S., Kiebler, M., Dormann, D., Ninkovic, J. (2022) TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. Nature Neuroscience. 25(12):1608-1625
- Campbell, C.A., Fursova, O., Cheng, X., Snella, E., McCune, A., Li, L., Solchenberger, B., Schmid, B., Sahoo, D., Morton, M., Traver, D., Espín-Palazón, R. (2021) A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood advances. 5:796-811
- Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
- Zhu, J., Xu, H., Song, H., Li, X., Wang, N., Zhao, J., Zheng, X., Kim, K.Y., Zhang, H., Mao, Q., Xia, H. (2021) CRISPR/Cas9-mediated grna gene knockout leads to neurodevelopmental defects and motor behavior changes in zebrafish. Journal of neurochemistry. 157(3):520-531
- Takjoo, R., Wilson, D., Bansal, P.S., Loukas, A., Smout, M.J., Daly, N.L. (2020) Folding of Truncated Granulin Peptides. Biomolecules. 10(8):
- Zambusi, A., Pelin Burhan, Ö., Di Giaimo, R., Schmid, B., Ninkovic, J. (2020) Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon. Cells. 9(2):
- Rougeot, J., Torraca, V., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Sommer, F., Spaink, H.P., Meijer, A.H. (2019) RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in immunology. 10:832
- Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6
- Tsuruma, K., Saito, Y., Okuyoshi, H., Yamaguchi, A., Shimazawa, M., Goldman, D., Hara, H. (2018) Granulin 1 Promotes Retinal Regeneration in Zebrafish. Investigative ophthalmology & visual science. 59:6057-6066
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