Gene
grna
- ID
- ZDB-GENE-030131-8434
- Name
- granulin a
- Symbol
- grna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Involved in axon extension; liver development; and skeletal muscle acetylcholine-gated channel clustering. Predicted to localize to extracellular region. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); and neuronal ceroid lipofuscinosis 11. Orthologous to human GRN (granulin precursor).
- Genome Resources
- Note
- None
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu337 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | Alliance | Aphasia, primary progressive | 607485 |
| Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | Alliance | Frontotemporal lobar degeneration with ubiquitin-positive inclusions | 607485 |
| neuronal ceroid lipofuscinosis 11 | Alliance | Ceroid lipofuscinosis, neuronal, 11 | 614706 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Granulin | Granulin family | Granulin superfamily |
|---|---|---|---|---|
|
UniProtKB:I3ITR0
|
182 | |||
|
UniProtKB:Q8QGN9
|
873 | |||
|
UniProtKB:E9QI45
|
1049 | |||
|
UniProtKB:F1QNY0
|
873 | |||
|
UniProtKB:I3ISQ5
|
189 | |||
|
UniProtKB:I3ISF3
|
280 | |||
|
UniProtKB:E9QCA6
|
873 | |||
|
UniProtKB:I3IST4
|
147 |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl