Gene

grna

ID
ZDB-GENE-030131-8434
Name
granulin a
Symbol
grna Nomenclature History
Previous Names
  • grn
  • pgrn-a (1)
  • progranulin (1)
  • sb:eu337
  • wu:fb11g12
  • wu:fj18f05
  • zfPGRN-A (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Acts upstream of or within several processes, including neuron differentiation; sensory system development; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be active in extracellular region. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grna Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Alliance Aphasia, primary progressive 607485
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Alliance Frontotemporal dementia 2 607485
neuronal ceroid lipofuscinosis 11 Alliance Ceroid lipofuscinosis, neuronal, 11 614706
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Associated With grna Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000118 Granulin
Family IPR039036 Granulin family
Homologous_superfamily IPR037277 Granulin superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Granulin Granulin family Granulin superfamily
UniProtKB:A0A8M2BB97 InterPro 1138
UniProtKB:A0A8M9PEV4 InterPro 968
UniProtKB:A0A8M2BB61 InterPro 880
UniProtKB:A0A8M2BB98 InterPro 1053
UniProtKB:Q8QGN9 InterPro PDB 873
1 - 5 of 11 Show all
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA grna-201 (1) Ensembl 3,631 nt
mRNA grna-202 (1) Ensembl 4,160 nt
mRNA grna-203 (1) Ensembl 3,632 nt
mRNA grna-204 (1) Ensembl 567 nt
mRNA grna-205 (1) Ensembl 840 nt
1 - 5 of 8 Show all
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-grna polyclonal Mouse
1
Ab1-grna polyclonal Rabbit
  • IHC
  • WB
1
Ab2-grna monoclonal IgG2b Rat
1
1 - 3 of 3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
1 - 10 of 30
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