Gene
gnb1a
- ID
- ZDB-GENE-030131-823
- Name
- guanine nucleotide binding protein (G protein), beta polypeptide 1a
- Symbol
- gnb1a Nomenclature History
- Previous Names
-
- gnb1 (1)
- wu:fb50b09
- wu:fj94h04
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Involved in positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and autosomal dominant non-syndromic intellectual disability 42. Is expressed in several structures, including blastomere; brain; epidermis; fin; and sensory system. Orthologous to human GNB1 (G protein subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Xu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | Leukemia, acute lymphoblastic, somatic | 613065 |
| autosomal dominant intellectual developmental disorder 42 | Alliance | Intellectual developmental disorder, autosomal dominant 42 | 616973 |
| myelodysplastic syndrome | Alliance | Myelodysplastic syndrome, somatic | 614286 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001632 | G-protein, beta subunit |
| Family | IPR016346 | Guanine nucleotide-binding protein, beta subunit |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Length | G-protein, beta subunit | G-protein beta WD-40 repeat | Guanine nucleotide-binding protein, beta subunit | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PH57
|
340 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available