Gene
hspa4b
- ID
- ZDB-GENE-030131-6018
- Name
- heat shock protein 4b
- Symbol
- hspa4b Nomenclature History
- Previous Names
-
- hspa4
- wu:fi30e11
- zgc:55743
- zgc:77413
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be involved in protein folding. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; head; liver; neural rod; and pectoral fin bud. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018884Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018885Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9130 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18551 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
| Domain | IPR042052 | HSPA4, nucleotide-binding domain |
| Family | IPR013126 | Heat shock protein 70 family |
| Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
| Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATPase, nucleotide binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily | HSPA4, nucleotide-binding domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUM5 | InterPro | 840 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hspa4b-201
(1)
|
Ensembl | 3,010 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-119P14 | ZFIN Curated Data | |
| Encodes | EST | fb81d05 | Rauch et al., 2003 | |
| Encodes | EST | fi30e11 | ||
| Encodes | cDNA | MGC:55743 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77413 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199857 (1) | 2979 nt | ||
| Genomic | GenBank:BX530085 (1) | 227326 nt | ||
| Polypeptide | UniProtKB:Q7ZUM5 (1) | 840 aa |
- Chen, X.K., Kwan, J.S., Wong, G.T., Yi, Z.N., Ma, A.C., Chang, R.C. (2022) Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Experimental & molecular medicine. 54(7):973-987
- Cambier, S., Røgeberg, M., Georgantzopoulou, A., Serchi, T., Karlsson, C., Verhaegen, S., Iversen, T.G., Guignard, C., Kruszewski, M., Hoffmann, L., Audinot, J.N., Ropstad, E., Gutleb, A.C. (2018) Fate and effects of silver nanoparticles on early life-stage development of zebrafish (Danio rerio) in comparison to silver nitrate. The Science of the total environment. 610-611:972-982
- Xu, K., Xu, H., Han, Z. (2018) Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Genes. 9(12)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Yin, X., Wang, H., Zhang, Y., Dahlgren, R.A., Zhang, H., Shi, M., Gao, M., Wang, X. (2014) Toxicological Assessment of Trace β-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis. PLoS One. 9:e102731
- Liu, C., Xu, H., Lam, S.H., and Gong, Z. (2013) Selection of Reliable Biomarkers from PCR Array Analyses Using Relative Distance Computational Model: Methodology and Proof-of-Concept Study. PLoS One. 8(12):e83954
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Crawford, K.C., Flores, M.V., Oehlers, S.H., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2011) Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation. Genesis (New York, N.Y. : 2000). 49(12):905-11
- Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418
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