Gene
ska3
- ID
- ZDB-GENE-030131-2997
- Name
- spindle and kinetochore associated complex subunit 3
- Symbol
- ska3 Nomenclature History
- Previous Names
-
- fc23d11
- si:rp71-68n21.13
- wu:fc23d11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and regulation of microtubule polymerization or depolymerization. Predicted to act upstream of or within cell division. Predicted to be located in meiotic spindle and mitotic spindle. Predicted to be part of outer kinetochore. Predicted to be active in kinetochore and spindle microtubule. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ramachandran et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026801Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17736 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR033341 | Spindle and kinetochore-associated protein 3 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Spindle and kinetochore-associated protein 3 |
|---|---|---|---|
| UniProtKB:Q58EL7 | InterPro | 495 | |
| UniProtKB:A0A8M1P1R9 | InterPro | 495 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-68N21 | ZFIN Curated Data | |
| Encodes | EST | fc23d11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001202437 (1) | 1790 nt | ||
| Genomic | GenBank:CU151884 (1) | 200118 nt | ||
| Polypeptide | UniProtKB:A0A8M1P1R9 (1) | 495 aa |
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ramachandran, R., Zhao, X.F., and Goldman, D. (2012) Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Nature cell biology. 14(10):1013-1023
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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