Gene
brd4
- ID
- ZDB-GENE-030131-267
- Name
- bromodomain containing 4
- Symbol
- brd4 Nomenclature History
- Previous Names
-
- fb18g03
- wu:fb18g03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Exhibits chromatin binding activity and histone binding activity. Involved in thrombocyte differentiation. Localizes to condensed chromosome and nucleus. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Is expressed in several structures, including blastoderm; blastodisc; notochord; post-vent region; and tail bud. Orthologous to human BRD4 (bromodomain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Toyama et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bielczyk-Maczyńska et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cornelia de Lange syndrome 6 | Alliance | Cornelia de Lange syndrome 6 | 620568 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR027353 | NET domain |
| Domain | IPR031354 | Bromodomain protein 4, C-terminal |
| Domain | IPR043508 | Brdt, bromodomain, repeat I |
| Domain | IPR043509 | Brdt, bromodomain, repeat II |
| Family | IPR050935 | Bromodomain-containing chromatin reader |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR038336 | NET domain superfamily |
Domain Details Per Protein
| Protein | Length | Brdt, bromodomain, repeat I | Brdt, bromodomain, repeat II | Bromodomain | Bromodomain, conserved site | Bromodomain-containing chromatin reader | Bromodomain-like superfamily | Bromodomain protein 4, C-terminal | NET domain | NET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R5H6
|
1444 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-brd4 | polyclonal | IgG | Rabbit |
|
Spring Valley Laboratories, Inc.
|
2 |
Plasmids
No data available