ZFIN is now using GRCz12tu for Genomic Data
Gene
brd4
- ID
- ZDB-GENE-030131-267
- Name
- bromodomain containing 4
- Symbol
- brd4 Nomenclature History
- Previous Names
-
- fb18g03
- wu:fb18g03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables chromatin binding activity and histone binding activity. Acts upstream of or within thrombocyte differentiation. Located in condensed chromosome and nucleus. Is expressed in several structures, including blastoderm; blastodisc; notochord; post-vent region; and tail bud. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Toyama et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bielczyk-Maczyńska et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cornelia de Lange syndrome 6 | Alliance | Cornelia de Lange syndrome 6 | 620568 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR027353 | NET domain |
| Domain | IPR031354 | Bromodomain protein 4, C-terminal |
| Domain | IPR043508 | Brdt, bromodomain, repeat I |
| Domain | IPR043509 | Brdt, bromodomain, repeat II |
| Family | IPR050935 | Bromodomain-containing chromatin reader |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR038336 | NET domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Brdt, bromodomain, repeat I | Brdt, bromodomain, repeat II | Bromodomain | Bromodomain, conserved site | Bromodomain-containing chromatin reader | Bromodomain-like superfamily | Bromodomain protein 4, C-terminal | NET domain | NET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R5H6 | InterPro | 1444 | |||||||||
| UniProtKB:A0AB32TDX9 | InterPro | 1442 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-brd4 | polyclonal | IgG | Rabbit |
|
Spring Valley Laboratories, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers