Gene
flrt3
- ID
- ZDB-GENE-030131-1988
- Name
- fibronectin leucine rich transmembrane 3
- Symbol
- flrt3 Nomenclature History
- Previous Names
-
- fb93g11
- si:dkeyp-24h12.1
- wu:fb75d02
- wu:fb93g11 (1)
- wu:fc10a05
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within cell adhesion. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; extracellular region; and focal adhesion. Predicted to be active in extracellular space. Is expressed in several structures, including mesoderm; midbrain hindbrain boundary neural keel; nervous system; optic primordium; and optic vesicle. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu497 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 21 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 21 with anosmia | 615271 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR003961 | Fibronectin type III |
| Family | IPR050333 | Small Leucine-Rich Proteoglycans |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Fibronectin type III | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Small Leucine-Rich Proteoglycans |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A507 | InterPro | 649 |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-24H12 | ZFIN Curated Data | |
| Encodes | EST | eu497 | Thisse et al., 2005 | |
| Encodes | EST | fb75d02 | ||
| Encodes | EST | fb93g11 | ||
| Encodes | EST | fc10a05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256646 (1) | 4229 nt | ||
| Genomic | GenBank:BX465200 (2) | 65108 nt | ||
| Polypeptide | UniProtKB:B8A507 (1) | 649 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Crosnier, C., Staudt, N., and Wright, G.J. (2010) A rapid and scalable method for selecting recombinant mouse monoclonal antibodies. BMC Biology. 8:76
- Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665
- Söllner, C., and Wright, G.J. (2009) A cell surface interaction network of neural leucine-rich repeat receptors. Genome biology. 10(9):R99
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