Gene

flrt3

ID

ZDB-GENE-030131-1988

Name

fibronectin leucine rich transmembrane 3

Symbol

flrt3 Nomenclature History

Previous Names

fb93g11
si:dkeyp-24h12.1
wu:fb75d02
wu:fb93g11 (1)
wu:fc10a05

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including mesoderm; midbrain hindbrain boundary neural keel; nervous system; optic primordium; and optic vesicle. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu497 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With flrt3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 21 with or without anosmia	Alliance	Hypogonadotropic hypogonadism 21 with anosmia	615271

Associated With flrt3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000372	Leucine-rich repeat N-terminal domain
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Domain	IPR003961	Fibronectin type III
Family	IPR050333	Small Leucine-Rich Proteoglycans
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype