Gene
racgap1
- ID
- ZDB-GENE-030131-1917
- Name
- Rac GTPase activating protein 1
- Symbol
- racgap1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Acts upstream of or within heart development; microtubule cytoskeleton organization; and mitotic cytokinesis. Predicted to be part of centralspindlin complex. Predicted to be active in several cellular components, including cleavage furrow; midbody; and spindle midzone. Is expressed in blastoderm; blastodisc; brain; nervous system; and proliferative region. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IIIb. Orthologous to human RACGAP1 (Rac GTPase activating protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77839 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022679Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| ta52a | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISRP1-racgap1 | Edwards et al., 2020 | |
| MO1-racgap1 | N/A | Warga et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital dyserythropoietic anemia type IIIb | Alliance | Anemia, congenital dyserythropoietic, type IIIb, autosomal recessive | 619789 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|---|
| UniProtKB:Q6P3H8 | InterPro | 654 | ||||
| UniProtKB:A0A0R4IZK0 | InterPro | 639 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
racgap1-201
(1)
|
Ensembl | 2,719 nt | ||
| mRNA |
racgap1-202
(1)
|
Ensembl | 1,389 nt | ||
| mRNA |
racgap1-204
(1)
|
Ensembl | 5,972 nt | ||
| ncRNA |
racgap1-003
(1)
|
Ensembl | 845 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-210C8 | ZFIN Curated Data | |
| Contains | SNP | rs3729269 | ZFIN Curated Data | |
| Contains | SNP | rs3729270 | ZFIN Curated Data | |
| Contains | SNP | rs3729271 | ZFIN Curated Data | |
| Encodes | EST | fb92c08 | ||
| Encodes | cDNA | MGC:77839 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199631 (1) | 2224 nt | ||
| Genomic | GenBank:CR354542 (1) | 157560 nt | ||
| Polypeptide | UniProtKB:Q6P3H8 (1) | 654 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | RACGAP1 | 12 | Amino acid sequence comparison (1) |
- Edwards, J.J., Rouillard, A.D., Fernandez, N.F., Wang, Z., Lachmann, A., Shankaran, S.S., Bisgrove, B.W., Demarest, B., Turan, N., Srivastava, D., Bernstein, D., Deanfield, J., Giardini, A., Porter, G., Kim, R., Roberts, A.E., Newburger, J.W., Goldmuntz, E., Brueckner, M., Lifton, R.P., Seidman, C.E., Chung, W.K., Tristani-Firouzi, M., Yost, H.J., Ma'ayan, A., Gelb, B.D. (2020) Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC. Basic to translational science. 5:376-386
- González-Rosa, J.M., Sharpe, M., Field, D., Soonpaa, M.H., Field, L.J., Burns, C.E., Burns, C.G. (2018) Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. Developmental Cell. 44:433-446.e7
- Warga, R.M., Wicklund, A., Richards, S.E., Kane, D.A. (2016) Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development. Developmental Biology. 418(2):307-22
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Li, Y., Chia, J.M., Bartfai, R., Christoffels, A., Ding, K., Yue, G.H., Ho,M.Y., Hill, J.A., Stupka, E. and Orban, L (2004) Comparative analysis of the testis and ovary transcriptomes in zebrafish by combining experimental and computational tools. Comparative and functional genomics. 5(5):403-418
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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