ZFIN ID: ZDB-GENE-021217-3
Gene Name: ADP-ribosylation factor-like 13b
Gene Symbol: arl13b    Nomenclature History

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Previous Names: arl2l1 (1), chunp6872, dkfzp761h079, fc23g07, scorpion (1), un-named hi459 (1), unm hi459 (1), wu:fc23g07 (1), zgc:123149

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have GTP binding activity. Involved in cilium assembly and photoreceptor cell outer segment organization. Localizes to cilium. Is expressed in Kupffer's vesicle; nervous system; otic vesicle; and pronephros. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to human ARL13B (ADP ribosylation factor like GTPase 13B).
Genome Resources: Alliance (1),  Gene:286784 (1),  Ensembl(GRCz11):ENSDARG00000012763 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi459Tg Transgenic Insertion 5' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17422 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25614 Point Mutation Unknown Splice Site ENU
    sa25615 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-arl13b N/A 6
    MO2-arl13b N/A 1
    DISEASE ASSOCIATED WITH arl13b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Joubert syndrome 8 Alliance Joubert syndrome 8 612291
    DISEASE ASSOCIATED WITH arl13b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component cilium (more)
    Molecular Function GTP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arl13b-201 (1)    Ensembl 2808
    arl13b-202 (1)    Ensembl 2153
    ncRNA arl13b-003 (1) 520
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-arl13b polyclonal Rabbit IHC, WB Covance
    9
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arl13b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(arl13b:EGFP,myl7:EGFP) arl13bmyl7 EGFP Danio rerio 1 4
    Tg(ubb:arl13b-EGFP) ubb arl13bEGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    arl13b Contained in: [BAC] DKEYP-8H3 (1)
    arl13b Encodes: [EST] fc23g07 (1)
    [STS] chunp6872
    [cDNA] MGC:123149 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173272 (1) 2808 nt
    Genomic GenBank:CR762462 (1) 186636 nt
    Select Tool
    Polypeptide UniProtKB:Q8JHI3 (1) 407 aa
    Sequence Information (all 18)
    ORTHOLOGY for arl13b ( Chr: 1 )
    CITATIONS (50)