Gene

ptgs1

ID
ZDB-GENE-020530-1
Name
prostaglandin-endoperoxide synthase 1
Symbol
ptgs1 Nomenclature History
Previous Names
  • Cox-1 (1)
  • Cox-1b (1)
  • cox1 (1)
  • zCOX-1 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits peroxidase activity and prostaglandin-endoperoxide synthase activity. Involved in animal organ development; cellular response to organic cyclic compound; and vasculogenesis. Is expressed in several structures, including cardiovascular system; digestive system; eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptgs1 Human Ortholog
No data available
Associated With ptgs1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Family IPR019791 Haem peroxidase, animal-type
Family IPR029580 Prostaglandin G/H synthase 1
Homologous_superfamily IPR010255 Haem peroxidase superfamily
Homologous_superfamily IPR037120 Haem peroxidase domain superfamily, animal type
Domain Details Per Protein
Protein Length EGF-like domain Haem peroxidase, animal-type Haem peroxidase domain superfamily, animal type Haem peroxidase superfamily Prostaglandin G/H synthase 1
UniProtKB:A0A2R8QJU6 609
UniProtKB:F1R0R6 597
UniProtKB:Q1JPW2 597
UniProtKB:Q8JH44 597
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations