ZFIN ID: ZDB-GENE-020424-3
Gene Name: lamin A
Gene Symbol: lmna    Nomenclature History

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Previous Names: cb948 (1), wu:fk66d12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Involved in heart contraction and regulation of cell aging. Predicted to localize to intermediate filament. Is expressed in several structures, including fin; head; mesoderm; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C).
Genome Resources: Alliance (1),  Gene:195815 (1),  Ensembl(GRCz11):ENSDARG00000013415 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hsi9 Complex Unknown Unknown CRISPR
la027723Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10537 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13189 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22872 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lmna 1
    MO1-lmna N/A 1
    MO2-lmna N/A 1
    MO3-lmna N/A 1
    MO4-lmna N/A 1
    MO5-lmna N/A 1
    DISEASE ASSOCIATED WITH lmna HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant Emery-Dreifuss muscular dystrophy 2 Alliance Emery-Dreifuss muscular dystrophy 2, autosomal dominant 181350
    autosomal recessive Emery-Dreifuss muscular dystrophy 3 Alliance Emery-Dreifuss muscular dystrophy 3, autosomal recessive 616516
    Charcot-Marie-Tooth disease type 2B1 Alliance Charcot-Marie-Tooth disease, type 2B1 605588
    congenital muscular dystrophy due to LMNA mutation Alliance Muscular dystrophy, congenital 613205
    dilated cardiomyopathy 1A Alliance Cardiomyopathy, dilated, 1A 115200
    dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome Alliance Malouf syndrome 212112
    familial partial lipodystrophy type 2 Alliance Lipodystrophy, familial partial, type 2 151660
    lethal restrictive dermopathy Alliance Restrictive dermopathy, lethal 275210
    progeria Alliance Hutchinson-Gilford progeria 176670
    Heart-hand syndrome, Slovenian type 610140
    Mandibuloacral dysplasia 248370
    DISEASE ASSOCIATED WITH lmna VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component intermediate filament (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lmna-202 (1)    Ensembl 4620
    ncRNA lmna-002 (1)    Ensembl 688
    lmna-003 (1)    Ensembl 412
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lmna polyclonal IgY Chicken IHC, WB Abcam plc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lmna
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.67lmna:EGFP) lmna EGFP Danio rerio 2 1
    Tg(-2.99lmna:EGFP) lmna EGFP Danio rerio 2 2
    Tg(tnnt2a:EGFP-lmna) tnnt2a EGFPlmna Danio rerio 1 1
    Tg(tnnt2a:EGFP-lmna_M368K) tnnt2a EGFPlmna Danio rerio 1 1
    Tg(tnnt2a:EGFP-lmna_Q291P) tnnt2a EGFPlmna Danio rerio 1 1
    Tg1(CMV:EGFP-lmna) EGFPlmna Danio rerio 1 3
    Tg2(CMV:EGFP-lmna) EGFPlmna Danio rerio 1 3
    Tg3(CMV:EGFP-lmna) EGFPlmna Danio rerio 1 3
    MARKER RELATIONSHIPS
    lmna Contained in: [BAC] DKEY-181C1 (1) (order this)
    lmna Encodes: [EST] cb948 (1) (order this), fk66d12 (1), wz10
    [cDNA] MGC:195196 (1), MGC:195205 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152971 (1) 2078 nt
    Genomic GenBank:CR848742 (1) 177769 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QPG3 (1) 675 aa
    Sequence Information (all 29)
    ORTHOLOGY for lmna ( Chr: 16 )
    CITATIONS (43)