Gene
spns1
- ID
- ZDB-GENE-020228-1
- Name
- SPNS lysolipid transporter 1, lysophospholipid
- Symbol
- spns1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane transporter activity. Acts upstream of or within autophagosome maturation and cellular senescence. Predicted to be located in lysosomal membrane. Predicted to be active in membrane. Is expressed in yolk syncytial layer. Orthologous to human SPNS1 (SPNS lysolipid transporter 1, lysophospholipid).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55239 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator superfamily | Major facilitator superfamily domain | MFS transporter superfamily | Protein spinster-like |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU13 | InterPro | 506 | ||||
| UniProtKB:G1K2F4 | InterPro | 504 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-66P13 | ZFIN Curated Data | |
| Contains | SNP | rs3727685 | ZFIN Curated Data | |
| Contains | SNP | rs3727686 | ZFIN Curated Data | |
| Contains | SNP | rs3727687 | ZFIN Curated Data | |
| Contains | SNP | rs3727688 | ZFIN Curated Data | |
| Contains | SNP | rs3727689 | ZFIN Curated Data | |
| Encodes | EST | fb95b12 | Young et al., 2002 | |
| Encodes | EST | fi37e11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55239 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192713 | ZFIN Curated Data |
1 - 10 of 10
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_153663 (1) | 2666 nt | ||
| Genomic | GenBank:CR388069 (1) | 219206 nt | ||
| Polypeptide | UniProtKB:Q7ZU13 (1) | 506 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- He, M., Kuk, A.C.Y., Ding, M., Chin, C.F., Galam, D.L.A., Nah, J.M., Tan, B.C., Yeo, H.L., Chua, G.L., Benke, P.I., Wenk, M.R., Ho, L., Torta, F., Silver, D.L. (2022) Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage. Proceedings of the National Academy of Sciences of the United States of America. 119:e2210353119
- Coffey, E.C., Astumian, M., Alrowaished, S.S., Schaffer, C., Henry, C.A. (2021) Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. Journal of developmental biology. 9(4):
- Khan, A., Fahad, T.M., Akther, T., Zaman, T., Hasan, M.F., Islam Khan, M.R., Islam, M.S., Kishi, S. (2020) Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish. Journal of Cellular and Molecular Medicine. 25(2):1048-1059
- Perland, E., Bagchi, S., Klaesson, A., Fredriksson, R. (2017) Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Open Biology. 7(9)
- Sasaki, T., Lian, S., Khan, A., Llop, J.R., Samuelson, A.V., Chen, W., Klionsky, D.J., Kishi, S. (2017) Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy. 13(2):386-403
- Sasaki, T., Lian, S., Qi, J., Bayliss, P.E., Carr, C.E., Johnson, J.L., Guha, S., Kobler, P., Catz, S.D., Gill, M., Jia, K., Klionsky, D.J., Kishi, S. (2014) Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency. PLoS Genetics. 10:e1004409
- Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A., and Mochizuki, N. (2009) The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors. Science (New York, N.Y.). 323(5913):524-527
- Kishi, S., Bayliss, P.E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., Amsterdam, A., and Roberts, T.M. (2008) The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genetics. 4(8):e1000152
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
1 - 10 of 14
Show