Gene
ckbb
- ID
- ZDB-GENE-020103-2
- Name
- creatine kinase, brain b
- Symbol
- ckbb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in extracellular space. Is expressed in several structures, including fin bud; nervous system; neural tube; prechordal plate; and trigeminal placode. Orthologous to human CKB (creatine kinase B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb594 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a257 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la013808Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17357 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ckbb | Thyme et al., 2019 | |
| CRISPR2-ckbb | Thyme et al., 2019 | |
| CRISPR3-ckbb | Thyme et al., 2019 | |
| CRISPR4-ckbb | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022415 | ATP:guanido phosphotransferase active site |
| Domain | IPR022413 | ATP:guanido phosphotransferase, N-terminal |
| Domain | IPR022414 | ATP:guanido phosphotransferase, catalytic domain |
| Family | IPR000749 | ATP:guanido phosphotransferase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
| Homologous_superfamily | IPR036802 | ATP:guanido phosphotransferase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP:guanido phosphotransferase | ATP:guanido phosphotransferase active site | ATP:guanido phosphotransferase, catalytic domain | ATP:guanido phosphotransferase, N-terminal | ATP:guanido phosphotransferase, N-terminal domain superfamily | Glutamine synthetase/guanido kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8AY63 | InterPro | 381 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
ckbb-203
(1)
|
Ensembl | 733 nt | ||
| aberrant processed transcript |
ckbb-205
(1)
|
Ensembl | 791 nt | ||
| mRNA |
ckbb-201
(1)
|
Ensembl | 1,464 nt | ||
| mRNA |
ckbb-204
(1)
|
Ensembl | 881 nt | ||
| mRNA |
ckbb-207
(1)
|
Ensembl | 861 nt | ||
| ncRNA |
ckbb-004
(1)
|
Ensembl | 597 nt | ||
| ncRNA |
ckbb-005
(1)
|
Ensembl | 947 nt | ||
| ncRNA |
ckbb-006
(1)
|
Ensembl | 516 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-271J4 | ZFIN Curated Data | |
| Encodes | EST | cb594 | Thisse et al., 2001 | |
| Encodes | EST | fj36f10 | ZFIN Curated Data | |
| Encodes | EST | fj37d11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56684 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77605 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173222 (1) | 1452 nt | ||
| Genomic | GenBank:BX248125 (1) | 66002 nt | ||
| Polypeptide | UniProtKB:Q8AY63 (1) | 381 aa |
- Faria, M., Prats, E., Gómez-Canela, C., Hsu, C.Y., Arick, M.A., Bedrossiantz, J., Orozco, M., Garcia-Reyero, N., Ziv, T., Ben-Lulu, S., Admon, A., Gómez-Oliván, L.M., Raldúa, D. (2019) Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Scientific Reports. 9:16467
- Jiao, Y., Yang, S., Min, G., Zhang, Y., Du, X., Wang, Q. (2019) Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Fish & shellfish immunology. 92:241-248
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Del Giacco, L., Binelli, A. (2018) Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 232:603-614
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Dong, X., Qiu, X., Meng, S., Xu, H., Wu, X., Yang, M. (2017) Proteomic profile and toxicity pathway analysis in zebrafish embryos exposed to bisphenol A and di-n-butyl phthalate at environmentally relevant levels. Chemosphere. 193:313-320
- Dong, X., Xu, H., Wu, X., Yang, L. (2017) Multiple bioanalytical method to reveal developmental biological responses in zebrafish embryos exposed to triclocarban. Chemosphere. 193:251-258
- Eastlake, K., Heywood, W.E., Tracey-White, D., Aquino, E., Bliss, E., Vasta, G.R., Mills, K., Khaw, P.T., Moosajee, M., Limb, G.A. (2017) Comparison of proteomic profiles in the zebrafish retina during experimental degeneration and regeneration. Scientific Reports. 7:44601
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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