|ZFIN ID: ZDB-PUB-011109-1|
A zebrafish nanos related gene is essential for the development of primordial germ cells
Köprunner, M., Thisse, C., Thisse, B., and Raz, E.
|Source:||Genes & Development 15(21): 2877-2885 (Journal)|
|Registered Authors:||Köprunner, Marion, Raz, Erez, Thisse, Bernard, Thisse, Christine|
|Keywords:||nanos; germ line; PGC; germ plasm; maternal RNA; cell migration; zebrafish|
|PubMed:||11691838 Full text @ Genes & Dev.|
Köprunner, M., Thisse, C., Thisse, B., and Raz, E. (2001) A zebrafish nanos related gene is essential for the development of primordial germ cells. Genes & Development. 15(21):2877-2885.
ABSTRACTAsymmetrically distributed cytoplasmic determinants collectively termed germ plasm have been shown to play an essential role in the development of primordial germ cells (PGCs). Here, we report the identification of a nanos-like (nanos1) gene, which is expressed in the germ plasm and in the PGCs of the zebrafish. We find that several mechanisms act in concert to restrict the activity of Nanos1 to the germ cells including RNA localization and control over the stability and translatability of the RNA. Reducing the level of Nanos1 in zebrafish embryos revealed an essential role for the protein in ensuring proper migration and survival of PGCs in this vertebrate model organism.