Community Action Needed: Please respond to the NIH RFI
Gene

mdkb

ID
ZDB-GENE-010131-6
Name
midkine b
Symbol
mdkb Nomenclature History
Previous Names
  • mdk2 (1)
  • mdk
  • cb518 (1)
  • fb79b05
  • fj33b02
  • fj48a12
  • plei2
  • pleiotrophin 2
  • wu:fb79b05 (1)
  • wu:fj33b02 (1)
  • wu:fj48a12 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable growth factor activity. Acts upstream of or within brain development; neural crest formation; and positive regulation of neuron differentiation. Located in extracellular region. Is expressed in several structures, including nervous system; neural keel; neural rod; neural tube; and presumptive neural plate. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Liedtke et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mdkb Human Ortholog
No data available
Associated With mdkb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020089 Pleiotrophin/Midkine, N-terminal domain
Domain IPR020090 Pleiotrophin/Midkine, C-terminal domain
Family IPR000762 Midkine heparin-binding growth factor
Homologous_superfamily IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamily
Homologous_superfamily IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamily
Homologous_superfamily IPR038130 Pleiotrophin/Midkine, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Midkine heparin-binding growth factor Pleiotrophin/Midkine, C-terminal domain Pleiotrophin/Midkine, C-terminal domain superfamily Pleiotrophin/Midkine disulphide-rich domain superfamily Pleiotrophin/Midkine, N-terminal domain Pleiotrophin/Midkine, N-terminal domain superfamily
UniProtKB:Q9DDG2 147
UniProtKB:Q9W768 147
UniProtKB:A0A0B5JK07 147
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations