Gene
mdkb
- ID
- ZDB-GENE-010131-6
- Name
- midkine b
- Symbol
- mdkb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have growth factor activity. Involved in brain development; neural crest formation; and positive regulation of neuron differentiation. Localizes to extracellular region. Human ortholog(s) of this gene implicated in brain ischemia. Is expressed in several structures, including nervous system; neural keel; neural rod; neural tube; and presumptive neural plate. Orthologous to human MDK (midkine).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb518 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Liedtke et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020089 | Pleiotrophin/Midkine, N-terminal domain |
| Domain | IPR020090 | Pleiotrophin/Midkine, C-terminal domain |
| Family | IPR000762 | Midkine heparin-binding growth factor |
| Homologous_superfamily | IPR020091 | Pleiotrophin/Midkine disulphide-rich domain superfamily |
| Homologous_superfamily | IPR037122 | Pleiotrophin/Midkine, N-terminal domain superfamily |
| Homologous_superfamily | IPR038130 | Pleiotrophin/Midkine, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Midkine heparin-binding growth factor | Pleiotrophin/Midkine, C-terminal domain | Pleiotrophin/Midkine, C-terminal domain superfamily | Pleiotrophin/Midkine disulphide-rich domain superfamily | Pleiotrophin/Midkine, N-terminal domain | Pleiotrophin/Midkine, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9DDG2
|
147 |
Interactions and Pathways
No data available
Plasmids
No data available