Gene
arnt2
- ID
- ZDB-GENE-001207-3
- Name
- aryl-hydrocarbon receptor nuclear translocator 2
- Symbol
- arnt2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Involved in regulation of DNA-templated transcription; response to hypoxia; and signal transduction. Acts upstream of or within several processes, including nervous system development; positive regulation of hypoxia-inducible factor-1alpha signaling pathway; and swim bladder inflation. Predicted to be located in cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including gut; hatching gland; mandibular arch skeleton; nervous system; and vasculature. Orthologous to human ARNT2 (aryl hydrocarbon receptor nuclear translocator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Webb-Dattani syndrome | 615926 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Family | IPR001067 | Nuclear translocator |
| Family | IPR050933 | Circadian Clock Transcription Factors |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Length | Circadian Clock Transcription Factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B3V4
|
723 | ||||||||
|
UniProtKB:Q9DG12
|
737 | ||||||||
|
UniProtKB:A0A0R4ID51
|
722 | ||||||||
|
UniProtKB:A0A8M3ATW0
|
738 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-arnt2 | monoclonal | IgG1 | Mouse |
|
Affinity BioReagents (Thermo Fisher Scientific)
|
2 |
Plasmids
No data available