Gene

csf1ra

ID
ZDB-GENE-001205-1
Name
colony stimulating factor 1 receptor, a
Symbol
csf1ra Nomenclature History
Previous Names
  • c-fms (1)
  • csf1r
  • fms (1)
  • pfe (1)
  • sal (1)
  • salz (1)
  • panther
  • pfeffer (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have macrophage colony-stimulating factor receptor activity. Involved in several processes, including immune response in brain or nervous system; macrophage chemotaxis; and myeloid leukocyte differentiation. Predicted to localize to CSF1-CSF1R complex; integral component of plasma membrane; and receptor complex. Is expressed in several structures, including hematopoietic cell; neural crest cell; osteoclast; pigment cell; and rostral blood island. Used to study CSF1R-related brain malformation and osteopetrosis. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Genome Resources
Note
None
Expression
All Expression Data
71 figures from 49 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
52 figures from 22 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With csf1ra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Alliance Leukoencephalopathy, diffuse hereditary, with spheroids 221820
Brain abnormalities, neurodegeneration, and dysosteosclerosis 618476
Associated With csf1ra Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR030658 Macrophage colony-stimulating factor 1 receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Macrophage colony-stimulating factor 1 receptor Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site
UniProtKB:A4JYH8 696
UniProtKB:B3DHL0 977
UniProtKB:A0A2R8QNM5 696
UniProtKB:Q9I8N6 977
UniProtKB:A0A2R8Q9U7 977
UniProtKB:A0A0R4IML5 883
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-csf1ra polyclonal IgG Rabbit
  • WB
AnaSpec
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations