ZFIN ID: ZDB-PUB-051121-5
Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence
Schweitzer, J., Becker, T., Schachner, M., Nave, K.A., and Werner, H.
Date: 2006
Source: Molecular and cellular neurosciences   31(1): 161-177 (Journal)
Registered Authors: Becker, Thomas, Schachner, Melitta, Schweitzer, Jörn
Keywords: Myelin protein evolution, Pelizaeus–Merzbacher disease, PLP/DM20, Gpm6a, Gpm6b, Tetraspan transmembrane proteins, Alternative splicing, Teleostei, Genome duplication, Nerve regeneration, Ascidian Ciona intestinalis, Drosophila melanogaster, Apis mellifera, Anopheles gambiae, Danio rerio, CNS regeneration, Remyelination, Neurite outgrowth, Optic nerve lesion
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Consensus Sequence
  • Evolution, Molecular*
  • Fishes/genetics*
  • Gene Duplication
  • Gene Expression Regulation*
  • Genetic Variation*
  • Genome
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Myelin Proteolipid Protein/chemistry
  • Myelin Proteolipid Protein/genetics*
  • Protein Conformation
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Zebrafish
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics
PubMed: 16289898 Full text @ Mol. Cell Neurosci.
The coevolution of neurons and their supporting glia to the highly specialized axon-myelin unit included the recruitment of proteolipids as neuronal glycoproteins (DMbeta, DMgamma) or myelin proteins (DMalpha/PLP/DM20). Consistent with a genome duplication at the root of teleosts, we identified three proteolipid pairs in zebrafish, termed DMalpha1 and DMalpha2, DMbeta1 and DMbeta2, DMgamma1 and DMgamma2. The paralogous amino acid sequences diverged remarkably after gene duplication, indicating functional specialization. Each proteolipid has adopted a distinct spatio-temporal expression pattern in neural progenitors, neurons, and in glia. DMalpha2, the closest homolog to mammalian PLP/DM20, is coexpressed with P0 in oligodendrocytes and upregulated after optic nerve lesion. DMgamma2 is expressed in multipotential stem cells, and the other four proteolipids are confined to subsets of CNS neurons. Comparing protein sequences and gene structures from birds, teleosts, one urochordate species, and four invertebrates, we have reconstructed major steps in the evolution of proteolipids.