Gene
cyp19a1b
- ID
- ZDB-GENE-001103-4
- Name
- cytochrome P450, family 19, subfamily A, polypeptide 1b
- Symbol
- cyp19a1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including response to estradiol; response to estrogen; and response to steroid hormone. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; ovarian disease (multiple); prostate disease (multiple); and urethral obstruction. Is expressed in several structures, including brain; cranial nerve; gonad; head; and radial glial cell. Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 67 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aromatase excess syndrome | Alliance | Aromatase excess syndrome | 139300 |
| Aromatase deficiency | 613546 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 Monooxygenases | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A890BQ19
|
||||||
|
UniProtKB:Q5U870
|
511 | |||||
|
UniProtKB:A0A8M9PGW6
|
513 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| pseudogenic transcript |
cyp19a1b-001
(1)
|
Ensembl | 4,167 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-cyp19a1b | polyclonal | Rabbit |
|
11 |
Plasmids
No data available