Gene
ybx1
- ID
- ZDB-GENE-000629-3
- Name
- Y box binding protein 1
- Symbol
- ybx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables several functions, including C5-methylcytidine-containing RNA reader activity; eukaryotic initiation factor 4E binding activity; and methyl-CpG binding activity. Involved in embryonic morphogenesis; mRNA stabilization; and negative regulation of translation. Acts upstream of or within establishment of RNA localization; negative regulation of mRNA splicing, via spliceosome; and negative regulation of translational initiation. Located in P-body and nucleus. Is expressed in blastoderm; blastodisc; blastomere; eye; and telencephalon. Orthologous to several human genes including YBX1 (Y-box binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55205 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ioz107 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| sa42 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa21381 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21382 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34489 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sg8 | Allele with one deletion | Exon 5 | Frameshift, Premature Stop | zinc finger nuclease | |
| tsu3d5i | Allele with one delins | Unknown | Premature Stop | CRISPR | |
| tsu27 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| umo60 | Allele with one deletion | Unknown | Unknown | TALEN | |
| zf2165 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cold-shock domain | Cold-shock domain, conserved site | Cold shock domain-containing protein | Cold-shock protein Csp, DNA-binding | Nucleic acid-binding, OB-fold |
|---|---|---|---|---|---|---|---|
| UniProtKB:B5DE31 | InterPro PDB | 310 |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(eef1a1l1:GFP-ybx1) |
|
| 1 | Sun et al., 2018 | |
| Tg(ybx1:ybx1-2A-GFP) |
|
|
| 2 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-100A1 | ZFIN Curated Data | |
| Encodes | EST | fb01g10 | ZFIN Curated Data | |
| Encodes | EST | fb08c05 | ZFIN Curated Data | |
| Encodes | EST | fb16e10 | Rauch et al., 2003 | |
| Encodes | EST | fj26c09 | ZFIN Curated Data | |
| Encodes | EST | zeh0308 | ||
| Encodes | cDNA | MGC:55205 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85599 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158477 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174067 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126457 (1) | 1515 nt | ||
| Genomic | GenBank:CR792439 (1) | 170028 nt | ||
| Polypeptide | UniProtKB:B5DE31 (1) | 310 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zhu, B., Zhang, Z., Pardeshi, L., Chen, Y., Ge, W. (2024) Role of Y box-binding protein 1 (Ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of p21 (cdkn1a). Development (Cambridge, England). 151(21):
- Lau, E.S., Zhu, B., Sun, M.A., Ngai, S.M., Ge, W. (2023) Proteomic analysis of zebrafish Folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian Folliculogenesis. Biology of reproduction. 109(4):482-497
- Nagorska, A., Zaucker, A., Lambert, F., Inman, A., Toral-Perez, S., Gorodkin, J., Wan, Y., Smutny, M., Sampath, K. (2023) Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function. Development (Cambridge, England). 150(23):
- Jamieson-Lucy, A.H., Kobayashi, M., James Aykit, Y., Elkouby, Y., Escobar-Aguirre, M., Vejnar, C., Giraldez, A., Mullins, M.C. (2022) A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb. Developmental Biology. 484:1-11
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
- Soto, R.A., Najia, M.A.T., Hachimi, M., Frame, J.M., Yette, G.A., Lummertz da Rocha, E., Stankunas, K., Daley, G.Q., North, T.E. (2021) Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports. 16(7):1718-1734
- Kwok, M.L., Chan, K.M. (2020) Oxidative stress and apoptotic effects of copper and cadmium in the zebrafish liver cell line ZFL. Toxicology reports. 7:822-835
- Lefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., Jerez-Longres, C., Onishi-Seebacher, M., Yin, N., Martagon-Calderón, N.A., Potts, K.S., Klaeylé, L., Liu, F., Bowman, T.V., Jenuwein, T., Mione, M.C., Trompouki, E. (2020) Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 53:934-951.e9
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