Gene
apaf1
- ID
- ZDB-GENE-000616-4
- Name
- apoptotic peptidase activating factor 1
- Symbol
- apaf1 Nomenclature History
- Previous Names
-
- zgc:136543
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable ADP binding activity; ATP binding activity; and peptidase activity. Predicted to act upstream of or within apoptotic signaling pathway; proteolysis; and regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of apoptosome. Is expressed in skeletal muscle. Orthologous to human APAF1 (apoptotic peptidase activating factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001315 | CARD domain |
| Domain | IPR002182 | NB-ARC |
| Domain | IPR037963 | Apoptotic Protease-Activating Factor 1, CARD domain |
| Domain | IPR041452 | APAF-1 helical domain |
| Domain | IPR048975 | Apoptotic protease-activating factor 1, winged-helix domain |
| Family | IPR017251 | Apoptotic protease-activating factor 1 |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR042197 | Apoptotic protease-activating factors, helical domain |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | APAF-1 helical domain | Apoptotic protease-activating factor 1 | Apoptotic Protease-Activating Factor 1, CARD domain | Apoptotic protease-activating factor 1, winged-helix domain | Apoptotic protease-activating factors, helical domain | CARD domain | Death-like domain superfamily | G-protein beta WD-40 repeat | NB-ARC | P-loop containing nucleoside triphosphate hydrolase | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9I9H8 | InterPro | 1261 | |||||||||||||||
| UniProtKB:A0A8M2BC28 | InterPro | 1261 | |||||||||||||||
| UniProtKB:A0AB32TM52 | InterPro | 1300 |
Interactions and Pathways
No data available
Plasmids
No data available