Gene
apaf1
- ID
- ZDB-GENE-000616-4
- Name
- apoptotic peptidase activating factor 1
- Symbol
- apaf1 Nomenclature History
- Previous Names
-
- zgc:136543
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable ADP binding activity; ATP binding activity; and peptidase activity. Predicted to act upstream of or within apoptotic signaling pathway; proteolysis; and regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of apoptosome. Is expressed in skeletal muscle. Orthologous to human APAF1 (apoptotic peptidase activating factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024463Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024464Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10293 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14399 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16025 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | APAF-1 helical domain | Apoptotic protease-activating factor 1 | Apoptotic Protease-Activating Factor 1, CARD domain | Apoptotic protease-activating factor 1, winged-helix domain | Apoptotic protease-activating factors, helical domain | CARD domain | Death-like domain superfamily | G-protein beta WD-40 repeat | NB-ARC | P-loop containing nucleoside triphosphate hydrolase | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9I9H8 | InterPro | 1261 | |||||||||||||||
| UniProtKB:A0A8M2BC28 | InterPro | 1261 | |||||||||||||||
| UniProtKB:A0AB32TM52 | InterPro | 1300 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173P13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92565 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136543 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131608 (1) | 3786 nt | ||
| Genomic | GenBank:CT025647 (1) | 113990 nt | ||
| Polypeptide | UniProtKB:A0AB32TM52 (1) | 1300 aa |
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Li, X., Zeng, L., Qu, Z., Zhang, F. (2023) Huoxin pill protects verapamil-induced zebrafish heart failure through inhibition of oxidative stress-triggered inflammation and apoptosis. Heliyon. 10:e23402e23402
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Xie, Z., Lu, G., Zhou, R., Ma, Y. (2022) Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). 246:106147
- Zhao, Y., Wang, H., Duah, P.A., Retyunskiy, V., Liu, Y., Chen, G. (2022) Zinc pyrithione (ZPT) -induced embryonic toxicogenomic responses reveal involvement of oxidative damage, apoptosis, endoplasmic reticulum (ER) stress and autophagy. Aquatic toxicology (Amsterdam, Netherlands). 248:106195
- Chen, X., Zheng, J., Teng, M., Zhang, J., Qian, L., Duan, M., Zhao, F., Zhao, W., Wang, Z., Wang, C. (2021) Bioaccumulation, Metabolism and the Toxic Effects of Chlorfenapyr in Zebrafish (Danio rerio). Journal of Agricultural and Food Chemistry. 69(29):8110-8119
- Godoi, F.G.A., Forner-Piquer, I., Randazzo, B., Habibi, H.R., Lo Nostro, F.L., Moreira, R.G., Carnevali, O. (2021) Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. Frontiers in endocrinology. 12:677853
- Qiang, L., Cheng, J. (2021) Exposure to polystyrene microplastics impairs gonads of zebrafish (Danio rerio). Chemosphere. 263:128161
- Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
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