Gene

krt4

ID

ZDB-GENE-000607-83

Name

keratin 4

Symbol

krt4 Nomenclature History

Previous Names

krt8 (1)
cb59 (1)
cytokeratin (1)
etID20321.6 (1)
wu:fa91a11
wu:fd19e09 (1)
wu:fl23c09 (1)
zf-K8 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to localize to keratin filament. Is expressed in EVL; ectoderm; endocrine system; integument; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Meesmann corneal dystrophy 2; epidermolytic hyperkeratosis; hereditary mucosal leukokeratosis; ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT8 (keratin 8).

Genome Resources

Note

None

Expression

All Expression Data

38 figures from 19 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

cb59 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With krt4 Human Ortholog

No data available

Associated With krt4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018039	Intermediate filament protein, conserved site
Domain	IPR032444	Keratin type II head
Domain	IPR039008	Intermediate filament, rod domain
Family	IPR003054	Keratin, type II
Homologous_superfamily	IPR042180	Intermediate filament, rod domain, coil 1B