Gene
mespaa
- ID
- ZDB-GENE-000406-8
- Name
- mesoderm posterior aa
- Symbol
- mespaa Nomenclature History
- Previous Names
-
- mesp-a
- Mesp1 (1)
- mespa
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including blood vessel endothelial cell fate specification; gastrulation; and regionalization. Predicted to be active in nucleus. Is expressed in several structures, including blastoderm; hypoblast; margin; paraxial mesoderm; and presumptive paraxial mesoderm. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 2. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mespaa | Deshwar et al., 2016 | |
| MO1-mespaa | N/A | (2) |
| TALEN1-mespaa | Yabe et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 2 | Alliance | Spondylocostal dysostosis 2, autosomal recessive | 608681 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Mesogenin/MesP | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:Q9IB70 | InterPro | 223 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mespaa-201
(1)
|
Ensembl | 887 nt | ||
| mRNA |
mespaa-202
(1)
|
Ensembl | 2,344 nt | ||
| mRNA |
mespaa-203
(1)
|
Ensembl | 2,436 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-276A23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193584 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193614 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131551 (1) | 886 nt | ||
| Genomic | GenBank:CR848709 (2) | 153072 nt | ||
| Polypeptide | UniProtKB:Q9IB70 (1) | 223 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Deleted orthology data derived from Woods et al. (ZDB-PUB-050823-6 ).
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | MESP2 | 15 | Amino acid sequence comparison (2) |
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Fittipaldi, R., Floris, P., Proserpio, V., Cotelli, F., Beltrame, M., Caretti, G. (2021) The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Cells. 10(5):
- Prajapati, R.S., Mitter, R., Vezzaro, A., Ish-Horowicz, D. (2020) Greb1 is required for axial elongation and segmentation in vertebrate embryos. Biology Open. 9(2):
- Nittoli, V., Fortunato, A.E., Fasano, G., Coppola, U., Gentile, A., Maiella, S., Langellotto, F., Porreca, I., De Paolo, R., Marino, R., Fiengo, M., Donizetti, A., Aniello, F., Kondo, T., Ristoratore, F., Canzoniero, L.M.T., Duboule, D., Wilson, S.W., Sordino, P. (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene X. 2:100011
- Wang, Z., Ding, Z.C., Xu, Q.H., Liu, J.X. (2019) Metabolism responses to silver nanoparticles stresses during zebrafish embryogenesis. Elsevier Science. 222:991-1002
- Lin, C.Y., He, J.Y., Zeng, C.W., Loo, M.R., Chang, W.Y., Zhang, P.H., Tsai, H.J. (2017) microRNA-206 modulates an Rtn4a/Cxcr4a/Thbs3a axis in newly forming somites to maintain and stabilize the somite boundary formation of zebrafish embryos.. Open Biology. 7(7)
- Deshwar, A.R., Chng, S.C., Ho, L., Reversade, B., Scott, I.C. (2016) The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development. eLIFE. 5
- Deshwar, A.R., Onderisin, J.C., Aleksandrova, A., Yuan, X., Burrows, J.T., Scott, I.C. (2016) Mespaa can potently induce cardiac fates in zebrafish. Developmental Biology. 418(1):17-27
- Jimenez, L., Wang, J., Morrison, M.A., Whatcott, C., Soh, K.K., Warner, S., Bearss, D., Jette, C.A., Stewart, R.A. (2016) Phenotypic chemical screening using zebrafish neural crest reporters identifies retinoid acid as an inhibitor of epithelial morphogenesis. Disease models & mechanisms. 9(4):389-400
- Perez-Camps, M., Tian, J., Chng, S.C., Sem, K.P., Sudhaharan, T., Teh, C., Wachsmuth, M., Korzh, V., Ahmed, S., Reversade, B. (2016) Quantitative imaging reveals real-time Pou5f3-Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish. eLIFE. 5
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