Gene

psen2

ID
ZDB-GENE-000330-9
Name
presenilin 2
Symbol
psen2 Nomenclature History
Previous Names
  • pre2 (1)
  • zf-PS2
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have endopeptidase activity. Involved in several processes, including amyloid-beta formation; melanocyte differentiation; and nervous system development. Predicted to localize to several cellular components, including Z disc; ciliary rootlet; and dendritic shaft. Is expressed in female organism; heart; male organism; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Orthologous to human PSEN2 (presenilin 2).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With psen2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alzheimer's disease 4 Alliance Alzheimer disease-4 606889
dilated cardiomyopathy 1V Alliance Cardiomyopathy, dilated, 1V 613697
Associated With psen2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001108 Peptidase A22A, presenilin
Family IPR006639 Presenilin/signal peptide peptidase
Homologous_superfamily IPR042524 Presenilin, C-terminal
Domain Details Per Protein
Protein Length Peptidase A22A, presenilin Presenilin, C-terminal Presenilin/signal peptide peptidase
UniProtKB:Q6P0Y0 441
UniProtKB:Q90ZE4 441
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-psen2 polyclonal Sheep
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations