Gene
igf2bp3
- ID
- ZDB-GENE-000308-1
- Name
- insulin-like growth factor 2 mRNA binding protein 3
- Symbol
- igf2bp3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Exhibits mRNA 3'-UTR binding activity. Predicted to be involved in mRNA transport and regulation of translation. Predicted to localize to cytoplasm and nucleus. Is expressed in oocyte stage I and oocyte stage V. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hza57 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
hza58 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
la010361Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la010393Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la010533Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la020659Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa6552 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa36823 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa43262 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa45668 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-igf2bp3 | Ren et al., 2020 | |
CRISPR2-igf2bp3 | Vong et al., 2021 | |
MO1-igf2bp3 | N/A | Jones et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000504 | RNA recognition motif domain |
Domain | IPR004087 | K Homology domain |
Domain | IPR004088 | K Homology domain, type 1 |
Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
Protein | Length | K Homology domain | K Homology domain, type 1 | K Homology domain, type 1 superfamily | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IYT0
|
607 | ||||||
UniProtKB:B2GT58
|
582 | ||||||
UniProtKB:A0A8M9P1P8
|
322 | ||||||
UniProtKB:Q9PW80
|
582 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
aberrant processed transcript |
igf2bp3-202
(1)
|
Ensembl | 852 nt | ||
mRNA |
igf2bp3-201
(1)
|
Ensembl | 4,599 nt | ||
mRNA |
igf2bp3-203
(1)
|
Ensembl | 6,175 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-igf2bp3 | polyclonal | Mouse |
|
2 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-155K24 | ZFIN Curated Data | |
Encodes | EST | fb79c12 | ZFIN Curated Data | |
Encodes | EST | fe06h09 | ||
Encodes | cDNA | MGC:56031 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192856 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131491 (1) | 2612 nt | ||
Genomic | GenBank:BX469899 (1) | 184184 nt | ||
Polypeptide | UniProtKB:A0A0R4IYT0 (1) | 607 aa |
- Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
- Vong, Y.H., Sivashanmugam, L., Leech, R., Zaucker, A., Jones, A., Sampath, K. (2021) The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish. PLoS Genetics. 17:e1009667
- Dicks, S., Jürgensen, L., Leuschner, F., Hassel, D., Andrieux, G., Boerries, M. (2020) Cardiac Regeneration and Tumor Growth-What Do They Have in Common?. Frontiers in genetics. 11:586658
- Ren, F., Lin, Q., Gong, G., Du, X., Dan, H., Qin, W., Miao, R., Xiong, Y., Xiao, R., Li, X., Gui, J.F., Mei, J. (2020) Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish. Communications biology. 3:94
- Beaudoin, J.D., Novoa, E.M., Vejnar, C.E., Yartseva, V., Takacs, C.M., Kellis, M., Giraldez, A.J. (2018) Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Nature structural & molecular biology. 25(8):677-686
- Takahashi, K., Ishii, K., Yamashita, M. (2018) Staufen1, Kinesin1 and microtubule function in cyclin B1 mRNA transport to the animal polar cytoplasm of zebrafish oocytes. Biochemical and Biophysical Research Communications. 503(4):2778-2783
- Liu, D., Brewer, M.S., Chen, S., Hong, W., Zhu, Y. (2017) Transcriptomic Signatures for Ovulation in Vertebrates. General and comparative endocrinology. 247:74-86
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gaynes, J.A., Otsuna, H., Campbell, D.S., Manfredi, J.P., Levine, E.M., Chien, C.B. (2015) The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo. PLoS One. 10:e0134751
- Arslan-Ergul, A., and Adams, M.M. (2014) Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic. BMC Neuroscience. 15:29
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