Figure 9
Schematic mechanisms by which rs10520161 is involved in dental fluorosis development. The rs10520161 A and T alleles exhibited different binding efficiencies with control and fluoride-treated nuclear extracts. This differential binding may modulate ClC-3 transcription, leading to altered mRNA levels of several isoforms involved in fluoride transport. In the left panel, red and black arrows indicate the directions and relative extents of fluoride and chloride transport, respectively. Colored wavy lines represent different ClC-3 transcripts (blue, transcript b; green, transcript c; yellow, transcript X1). In the right panel, red arrows indicate promotion, whereas black T-shaped lines indicate inhibition. |