FIGURE

Figure 5

ID

ZDB-FIG-260730-26

Publication

Zhang et al., 2026 - CFTR and ClC-3 Transport Fluoride Differently and Cause Dental Fluorosis in Different Ways

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Figure 5

Correlation between fluoride and ClC-3 in DF mouse model. (A) Appearance of mouse incisors in control (upper lane) and DF mouse model (lower lane). (B) Histological changes in mouse incisors and the related ClC-3 changes. (a~f) H&E staining. Images a~f illustrate sequential stages of mouse mandibular incisor enamel differentiation. In the secretory stage, normal ameloblasts are tall, columnar and regularly aligned (a); they shorten during the transition (b) and maturation stages (c). In DF-treated samples, ameloblasts are irregularly arranged, cysts are present, and the enamel is malformed (d~f). (g~l): sABC immunohistochemical staining for CLC-3 in tooth. Images (h) shows strong positive staining for CLC-3 in ameloblasts at the transition stage in the control group. By contrast, positive staining for CLC-3 is observed in DF-treated ameloblasts at all three stages (j~l). Black arrows point to the ameloblasts. Scale bars = 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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