FIGURE

Fig. 1

ID

ZDB-FIG-260607-1

Publication

Perey-Simon et al., 2025 - dUTPase is essential in zebrafish development and possesses several single-nucleotide variants with pronounced structural and functional consequences

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Fig. 1

In silico analysis of Danio rerio dUTPase variants. (A) Sequence alignment of all Danio dUTPase variants each represented with their respective Uniprot code, which is colored corresponding to Panel B. Asterisk (*) denotes identity; strongly or weakly similar amino acids are marked with colon (:) and period (.) respectively. Positions of the variable residues are highlighted in yellow. The five conserved motifs are boxed. The protein variants corresponding to the underlined sequence lacking the N‐terminal extension were expressed. (B) The genomic location of the dut gene (green) on chromosome 18 and the exon composition of the three transcripts (named and colored as on Panel A) where active transcription can be detected. (C) Transcriptional start sites (TSSs) of the maternal and zygotic transcripts. Panels B and C were generated by Integrated Genome Viewer (IGV) [61].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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