FIGURE

Figure 7

ID

ZDB-FIG-260501-78

Publication

Kakiailatu et al., 2026 - Impact of enteric neuronal loss on intestinal cell composition

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Figure 7

Immunohistochemical validation and quantification in tissue collected from patients with HSCR

(A) IHC validation of 5-HT in control and HSCR aganglionic tissue. DAPI is shown in gray and 5-HT+ cells in magenta. Scale bars represent 100 μm.

(B) Graph shows a significant decrease of 5-HT+ cells per crypt in aganglionic tissue of patients with HSCR (∗∗: p = 0.0027, Student’s t test).

(C) IHC validation of CD45⁺ cells in control and HSCR aganglionic tissue. DAPI is depicted in gray and CD45⁺ cells in red. Scale bars represent 100 μm.

(D) Graph shows a significant increase of CD45⁺ cells in HSCR aganglionic tissue (∗∗: p = 0.008, Welch’s t test).

(E) IHC validation for BEST4 in control and HSCR aganglionic tissue, with zoomed-in views on the right. Scale bars represent 200 μm.

(F) Graph shows a significant decrease of BEST4+ enterocytes in aganglionic tissue of patients with HSCR (∗: p = 0.029, Student’s t test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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