FIGURE

Fig. 2

ID

ZDB-FIG-260330-38

Publication

Kim et al., 2026 - RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization

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Fig. 2

miR-190 overexpression significantly reduces rabep1 expression in neutrophils.(A) Volcano plot showing differentially expressed genes (DEGs) in miR-190 overexpressing (OE) neutrophils compared to vector controls. Down-regulated DEGs are depicted in cyan, and up-regulated DEGs in pink. Selected down-regulated DEGs based on screening criteria are highlighted in the plot. (B) GO enrichment analysis of significantly downregulated DEGs in miR-190-OE neutrophils. (C) Schematic of transient sgRNA-expressing plasmid injection into Cas9-expressing embryos to generate transient TSKO. sgRNA-expressing plasmids were designed to produce two separate sgRNAs targeting one specific gene at two different loci. (D) Quantification of neutrophil motility in transient TSKO screen. The assay included 3 biological repeats, each tracking 20-58 neutrophils from 5-8 fish per group. Data are presented as mean ± SD and analyzed using Dunnett's multiple comparisons test.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Leukoc. Biol.