FIGURE

FIGURE 5

ID

ZDB-FIG-260327-12

Publication

Chen et al., 2026 - Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish

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FIGURE 5

Inhibition of the mFAO exacerbates proteostasis impairment in atrophic zebrafish. (a) Western blot and quantification of poly-ubiquitinated proteins in the detergent-soluble and -insoluble fractions of the protein lysates from larval zebrafish treated with DEXA(S) and/or ETO (DEXA(S) indicates a short-course treatment. *p < 0.05, t-test, two-tailed, error bar indicates s.d.). (b) qRT-PCR analysis of zebrafish larvae treated with DEXA(S) and/or ETO showing the expression of the proteostasis genes hsp70.1 and sqstm1 (*p < 0.05, t-test, two-tailed, error bar indicates s.d.). (c) Left: schematic illustration of the hormesis treatment. Right: qPCR analysis of zebrafish treated with DEXA(S)+ETO with or without the hormesis treatment showing the expression of the atrophy genes fbxo32 and trim63a (*p < 0.05, t-test, two-tailed, error bar indicates s.d.).

Expression Data

Genes:	hsp70.1 sqstm1
Fish:	AB
Condition:	chemical treatment by environment: dexamethasone
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: dexamethasone chemical treatment by environment: dexamethasone
Observed In:	protein polyubiquitination whole organism
Stage:	Day 6

Phenotype Detail

Acknowledgments

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