FIGURE

Fig. 2

ID

ZDB-FIG-260322-25

Publication

Solheim et al., 2026 - Early motor deficits, sleep dysfunction and reduction in dopaminergic neurons in a PARK7^-/- zebrafish larval model of Parkinson's disease

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Fig. 2

PARK7^-/- larvae have lower sensorimotor responsiveness compared to wild types. Touch-evoke response of both head (A) and tail (B) show a significant decrease (**p < 0.01, ***p < 0.001; generalised linear model (GLM) with a quasibinomial distribution followed by Tukey-adjusted pairwise comparisons of model-adjusted means to assess the effects of genotype, drug and their interaction) in sensorimotor responses for PARK7^-/-. MPP⁺ further decreased responsiveness for both wild type and PARK7^-/- larvae. Values are the mean ± SEM (n = 48–84) per condition, sampled from 4–7 independent breedings.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT park7^{ub2000/ub2000}
Condition:	chemical treatment by environment: N-methyl-4-phenylpyridinium
Observed In:	caudal fin response to mechanical stimulus head response to mechanical stimulus
Stage:	Day 5

Phenotype Detail

Acknowledgments

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