FIGURE

Fig 1

ID

ZDB-FIG-251211-1

Publication

Jones et al., 2025 - The syntenic long non-coding RNA DANCR is an essential regulator of zebrafish development and a human melanoma oncogene

Other Figures

All Figure Page

Back to All Figure Page

Fig 1

DANCR is a candidate melanoma associated lncRNA expressed from equivalent genomic locations in vertebrates.

(A) Workflow used to identify human MITF-bound melanocyte and/or melanoma expressed lncRNAs that are transcribed from equivalent regions in the zebrafish genome. (B)DANCR lncRNA is expressed from syntenic regions in vertebrate genomes in an equivalent direction relative to the neighbouring USP46 and RASL11B protein-coding genes. (C)DANCR is a multi-exonic lncRNA that contains two snoRNAs embedded within separate introns in the human (GRCh37/hg19) and zebrafish (GRCz10/danRer11) genomes. (D, E)DANCR is cytoplasmically enriched in both human and zebrafish. Human SK-MEL-28 melanoma cells (D) and zebrafish embryonic cells (E) were biochemically separated into cytoplasmic and nuclear fractions. The relative levels of DANCR and the indicated nuclear transcript controls were determined in each fraction by RT-qPCR.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.