FIGURE

Fig. 8

ID

ZDB-FIG-251022-27

Publication

Flatman et al., 2025 - Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease

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Fig. 8

col4a1Δ20 mutant fish display spontaneous brain haemorrhages during adulthood. A. Two adult homozygous (col4a1Δ20/Δ20) zebrafish viewed dorsally with a cephalic ‘red patch’ (right, marked with an *) and one without (left) (lower panel). The dashed white outlined insert image is a representative image of a successfully dissected ‘red patch’. Above are the heads of wildtype (col4a1+/+) and heterozygous (col4a1+/Δ20) siblings. B. A diagram of the dorsal adult zebrafish brain adapted from [61] and created in Adobe Illustrator. C. Representative images of whole brains from adult sibling zebrafish at 12 months old. The top two panels are brains from col4a1+/+and col4a1+/Δ20fish and the bottom two panels are brains from col4a1Δ20/Δ20 fish with (right) and without (left) a visible ‘red patch’. The images below are magnifications of the regions indicated. The scale bar represents 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Matrix Biol.