Fig. 1

MMP-2/9 inhibition decreases locomotion independently from anxiety/stress in zebrafish.A Top panel: representative cartoon of the Open field tank with dimensions and water level. Bottom panel: representative heatmap of the explorative trajectory of a juvenile DMSO-treated zebrafish. B Quantification of total distance traveled and mean velocity for early juvenile zebrafish. C Quantification of total distance traveled and mean velocity for late juvenile/early adult zebrafish. D Top panel: representative cartoon of the Novel Tank with dimensions, water level, and division of top versus bottom compartments (red dashed line). Note that the same setup was used to measure both behaviors. Bottom panel: representative heatmap of the trajectory of a juvenile non-treated zebrafish showing their time in each compartment. E Quantification of the time spent on either top or bottom compartment in the Novel Tank test as well as latency to reach the top of the tank for early juvenile zebrafish. F Quantification of the same parameters for late juvenile/early adult zebrafish. Unpaired Student’s t and Mann-Whitney tests. Graphs are expressed as mean ± S.E.M. Data were acquired with EthoVision XT16 software. **p < 0.01. Created in BioRender. https://BioRender.com/bvwowsr.